The Lymph Node in HIV Pathogenesis

Overview

Journal Semin Immunol

Specialty Allergy & Immunology

Date 2008 Jul 16

PMID 18620868

Citations 28

Authors

Michael M Lederman

Leonid Margolis

Affiliations

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Abstract

Since the earliest days of the AIDS epidemic, clinicians and researchers have recognized the importance of lymphoid tissue both in the clinical manifestations of disease and in its pathogenesis. Generalized lymphadenopathy was one of the earliest harbingers of AIDS in the United States and over the past 27 years an increasing body of evidence has implicated the lymphoid organs as central to the pathogenesis of immune deficiency in chronic HIV-1 infection. In this essay, we will review some of the data that have been accumulated and propose a testable model that may reconcile them.

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References

Wolthers K, Bea G, Wisman A, Otto S, de Roda Husman A, Schaft N . T cell telomere length in HIV-1 infection: no evidence for increased CD4+ T cell turnover. Science. 1996; 274(5292):1543-7. DOI: 10.1126/science.274.5292.1543. View

Weaver C, Hatton R, Mangan P, Harrington L . IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol. 2007; 25:821-52. DOI: 10.1146/annurev.immunol.25.022106.141557. View

Tindall B, Barker S, Donovan B, Barnes T, Roberts J, Kronenberg C . Characterization of the acute clinical illness associated with human immunodeficiency virus infection. Arch Intern Med. 1988; 148(4):945-9. View

Schacker T, Reilly C, Beilman G, Taylor J, Skarda D, Krason D . Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count. AIDS. 2005; 19(18):2169-71. DOI: 10.1097/01.aids.0000194801.51422.03. View

Metroka C, Cunningham-Rundles S, Pollack M, Sonnabend J, Davis J, Gordon B . Generalized lymphadenopathy in homosexual men. Ann Intern Med. 1983; 99(5):585-91. DOI: 10.7326/0003-4819-99-5-585. View

Wu H, Connick E, Kuritzkes D, Landay A, Spritzler J, Zhang B . Multiple CD4+ cell kinetic patterns and their relationships with baseline factors and virological responses in HIV type 1 patients receiving highly active antiretroviral therapy. AIDS Res Hum Retroviruses. 2001; 17(13):1231-40. DOI: 10.1089/088922201750461285. View

Lane H, Depper J, Greene W, Whalen G, Waldmann T, Fauci A . Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. Evidence for a selective defect in soluble antigen recognition. N Engl J Med. 1985; 313(2):79-84. DOI: 10.1056/NEJM198507113130204. View

Brenchley J, Price D, Schacker T, Asher T, Silvestri G, Rao S . Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006; 12(12):1365-71. DOI: 10.1038/nm1511. View

Raffatellu M, Santos R, Verhoeven D, George M, Wilson R, Winter S . Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Nat Med. 2008; 14(4):421-8. PMC: 2901863. DOI: 10.1038/nm1743. View

10.

Sieg S, Bazdar D, Lederman M . S-phase entry leads to cell death in circulating T cells from HIV-infected persons. J Leukoc Biol. 2008; 83(6):1382-7. PMC: 4126612. DOI: 10.1189/jlb.0907643. View

11.

Bucy R, Hockett R, Derdeyn C, Saag M, Squires K, Sillers M . Initial increase in blood CD4(+) lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues. J Clin Invest. 1999; 103(10):1391-8. PMC: 408455. DOI: 10.1172/JCI5863. View

12.

Connick E, Lederman M, Kotzin B, Spritzler J, Kuritzkes D, St Clair M . Immune reconstitution in the first year of potent antiretroviral therapy and its relationship to virologic response. J Infect Dis. 1999; 181(1):358-63. DOI: 10.1086/315171. View

13.

Gardner M . SIV infected rhesus macaques: an AIDS model for immunoprevention and immunotherapy. Adv Exp Med Biol. 1989; 251:279-93. DOI: 10.1007/978-1-4757-2046-4_26. View

14.

Sieg S, Bazdar D, Lederman M . Impaired TCR-mediated induction of Ki67 by naive CD4+ T cells is only occasionally corrected by exogenous IL-2 in HIV-1 infection. J Immunol. 2003; 171(10):5208-14. DOI: 10.4049/jimmunol.171.10.5208. View

15.

Funderburg N, Luciano A, Jiang W, Rodriguez B, Sieg S, Lederman M . Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis. PLoS One. 2008; 3(4):e1915. PMC: 2271052. DOI: 10.1371/journal.pone.0001915. View

16.

Vassalli P . Gut intraepithelial T lymphocytes. Curr Opin Immunol. 1993; 5(2):247-52. DOI: 10.1016/0952-7915(93)90012-h. View

17.

Lempicki R, Kovacs J, Baseler M, Adelsberger J, Dewar R, Natarajan V . Impact of HIV-1 infection and highly active antiretroviral therapy on the kinetics of CD4+ and CD8+ T cell turnover in HIV-infected patients. Proc Natl Acad Sci U S A. 2000; 97(25):13778-83. PMC: 17652. DOI: 10.1073/pnas.250472097. View

18.

Picker L, Hagen S, Lum R, Reed-Inderbitzin E, Daly L, Sylwester A . Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection. J Exp Med. 2004; 200(10):1299-314. PMC: 2211921. DOI: 10.1084/jem.20041049. View

19.

Moir S, Malaspina A, Pickeral O, Donoghue E, Vasquez J, Miller N . Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily. J Exp Med. 2004; 200(7):587-99. View

20.

Schacker T, Collier A, Hughes J, Shea T, Corey L . Clinical and epidemiologic features of primary HIV infection. Ann Intern Med. 1996; 125(4):257-64. DOI: 10.7326/0003-4819-125-4-199608150-00001. View