Inoperable Esophageal Cancer and Outcome of Palliative Care

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2008 Jul 3

PMID 18595139

Citations 19

Authors

Sima Besharat

Ali Jabbari

Shahryar Semnani

Abbasali Keshtkar

Jeran Marjani

Affiliations

Soon will be listed here.

Abstract

Aim: To determine the outcome of esophageal cancer patients referred for palliative care, in Gorgan and Gonbad gastrointestinal clinics, northeast of Iran.

Methods: This cross-sectional study was done on inoperable esophageal cancer cases referred to gastrointestinal clinics in Gorgan and Gonbad city (2005-2006). Demographic data were collected during the procedure and cases were followed up every one month. Improvement proportion was calculated with 95% confidence interval, to determine the rate of improvement. Survival analysis and Kaplan-Meier methods were used to estimate the duration of palliative care effectiveness.

Results: We recruited 39 cases into the study. Squamous cell carcinoma was the most prevalent (92.3%). The middle third of the esophagus was involved predominantly (51.3%). Dilation was the most preferred method (89.7%) and stenting was done in 4 cases. Decreasing dysphagia score was not related to palliation method or pathology type of carcinoma. Age of the patients was significantly related to the improvement of dysphagia score. Mean survival time was 137.6 d and median was 103 d.

Conclusion: Results of this study showed a low survival rate after palliative care in esophageal cancer cases despite dysphagia scores' improvement after dilating or stenting.

Citing Articles

Sarcopenia reduces overall survival in unresectable oesophageal cancer: a systematic review and meta-analysis.

Jogiat U, Bedard E, Sasewich H, Turner S, Eurich D, Filafilo H J Cachexia Sarcopenia Muscle. 2022; 13(6):2630-2636.

PMID: 36151845 PMC: 9745498. DOI: 10.1002/jcsm.13082.

Clinical Effect and Postoperative Pain of Laparo-Thoracoscopic Esophagectomy in Patients with Esophageal Cancer.

Yu Y, Han Y Evid Based Complement Alternat Med. 2022; 2022:4507696.

PMID: 35795286 PMC: 9251098. DOI: 10.1155/2022/4507696.

Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma.

Xi Y, Lin Y, Guo W, Wang X, Zhao H, Miao C Signal Transduct Target Ther. 2022; 7(1):53.

PMID: 35210398 PMC: 8873499. DOI: 10.1038/s41392-022-00873-8.

Diagnostic Performance of Artificial Intelligence-Centred Systems in the Diagnosis and Postoperative Surveillance of Upper Gastrointestinal Malignancies Using Computed Tomography Imaging: A Systematic Review and Meta-Analysis of Diagnostic Accuracy.

Chidambaram S, Sounderajah V, Maynard N, Markar S Ann Surg Oncol. 2021; 29(3):1977-1990.

PMID: 34762214 PMC: 8810479. DOI: 10.1245/s10434-021-10882-6.

Current State of Palliative Care in Iran and Related Issues: A Narrative Review.

Bagheri I, Hashemi N, Bahrami M Iran J Nurs Midwifery Res. 2021; 26(5):380-391.

PMID: 34703775 PMC: 8491829. DOI: 10.4103/ijnmr.IJNMR_418_20.

References

Pultrum B, van Westreenen H, Mulder N, van Dullemen H, Plukker J . Outcome of palliative care regimens in patients with advanced oesophageal cancer detected during explorative surgery. Anticancer Res. 2006; 26(3B):2289-93. View

Javle M, Ailawadhi S, Yang G, Nwogu C, Schiff M, Nava H . Palliation of malignant dysphagia in esophageal cancer: a literature-based review. J Support Oncol. 2006; 4(8):365-73, 379. View

Dahan L, Ries P, Laugier R, Seitz J . [Palliative endoscopic treatments for esophageal cancers]. Gastroenterol Clin Biol. 2006; 30(2):253-61. DOI: 10.1016/s0399-8320(06)73162-1. View

Carreira J, Gorriz E, Reyes R, Argiles J, Pulido J, Pardo M . [Treatment of dysphagia of malignant origin with the endoprosthesis of Strecker]. Med Clin (Barc). 1998; 110(19):727-30. View

Schoppmeyer K, Golsong J, Schiefke I, Mossner J, Caca K . Antireflux stents for palliation of malignant esophagocardial stenosis. Dis Esophagus. 2007; 20(2):89-93. DOI: 10.1111/j.1442-2050.2007.00646.x. View

Cwikiel W, Tranberg K, Cwikiel M, Lillo-Gil R . Malignant dysphagia: palliation with esophageal stents--long-term results in 100 patients. Radiology. 1998; 207(2):513-8. DOI: 10.1148/radiology.207.2.9577503. View

Lecleire S, Di Fiore F, Antonietti M, Ben Soussan E, Hellot M, Grigioni S . Undernutrition is predictive of early mortality after palliative self-expanding metal stent insertion in patients with inoperable or recurrent esophageal cancer. Gastrointest Endosc. 2006; 64(4):479-84. DOI: 10.1016/j.gie.2006.03.930. View

Conigliaro R, Battaglia G, Repici A, De Pretis G, Ghezzo L, Bittinger M . Polyflex stents for malignant oesophageal and oesophagogastric stricture: a prospective, multicentric study. Eur J Gastroenterol Hepatol. 2007; 19(3):195-203. DOI: 10.1097/MEG.0b013e328013a418. View

Maroju N, Anbalagan P, Kate V, Ananthakrishnan N . Improvement in dysphagia and quality of life with self-expanding metallic stents in malignant esophageal strictures. Indian J Gastroenterol. 2006; 25(2):62-5. View

10.

Ross W, Alkassab F, Lynch P, Ayers G, Ajani J, Lee J . Evolving role of self-expanding metal stents in the treatment of malignant dysphagia and fistulas. Gastrointest Endosc. 2006; 65(1):70-6. DOI: 10.1016/j.gie.2006.04.040. View

11.

Winkelbauer F, Schofl R, Niederle B, Wildling R, Thurnher S, Lammer J . Palliative treatment of obstructing esophageal cancer with nitinol stents: value, safety, and long-term results. AJR Am J Roentgenol. 1996; 166(1):79-84. DOI: 10.2214/ajr.166.1.8571911. View

12.

Keller R, Flieger D, Fischbach W, Christl S . Self-expanding metal stents for malignant esophagogastric obstruction: experience with a new design covered nitinol stent. J Gastrointestin Liver Dis. 2007; 16(3):239-43. View

13.

Tangen M, Andresen S, Moum B, Hauge T . [Stent insertion as palliation of cancer in the esophagus and cardia]. Tidsskr Nor Laegeforen. 2006; 126(12):1607-9. View

14.

Carreira Villamor J, Reyes Perez R, Gorriz Gomez E, Pulido-Duque J, Argiles Vives J, Pardo Moreno M . [Wallstent endoprostheses implanted by fluoroscopic guidance in the palliative treatment of malignant esophageal obstructions and esophago-tracheal fistulas]. Nutr Hosp. 1997; 12(3):141-6. View

15.

Ferrante M, Feliziani M, Imperatori A, Ferraris L, Bernasconi G . Endoscopic palliation of esophageal cancer. Rays. 2006; 31(1):3-7. View