TDP-43 is a Culprit in Human Neurodegeneration, and Not Just an Innocent Bystander

Overview

Journal Mamm Genome

Specialty Genetics

Date 2008 Jul 2

PMID 18592312

Citations 35

Authors

Gareth T Banks

Anna Kuta

Adrian M Isaacs

Elizabeth M C Fisher

Affiliations

Soon will be listed here.

Abstract

In 2006 the protein TDP-43 was identified as the major ubiquitinated component deposited in the inclusion bodies found in two human neurodegenerative diseases, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. The pathogenesis of both disorders is unclear, although they are related by having some overlap of symptoms and now by the shared histopathology of TDP-43 deposition. Now, in 2008, several papers have been published in quick succession describing mutations in the TDP-43 gene, showing they can be a primary cause of amyotrophic lateral sclerosis. There are many precedents in neurodegenerative disease in which rare single-gene mutations have given great insight into understanding disease processes, which is why the TDP-43 mutations are potentially very important.

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