Depression Augments Activity-related Pain in Women but Not in Men with Chronic Musculoskeletal Conditions

Overview

Journal Pain Res Manag

Date 2008 Jul 2

PMID 18592061

Citations 5

Authors

H Adams

P Thibault

N Davidson

M Simmonds

A Velly

M J L Sullivan

Affiliations

Soon will be listed here.

Abstract

Objectives: The primary objective of the present study was to examine the role of sex as a moderator of the relation between depression and activity-related pain.

Methods: The study sample consisted of 83 participants (42 women, 41 men) with musculoskeletal conditions. Participants were asked to lift a series of 18 canisters that varied in weight (2.9 kg, 3.4 kg and 3.9 kg) and distance from the body. Participants were asked to rate their pain while they lifted each canister and estimate the weight of the canisters.

Results: Consistent with previous research, the relations among depression, pain intensity and disability were stronger for women than for men. ANOVA revealed that depression was associated with more intense activity-related pain in women only. For both women and men, the intensity of pain increased with each trial, although the weight of the objects lifted remained constant. Neither sex nor depression had an effect on participants' weight estimates.

Conclusions: The present discussion addresses the mechanisms through which depression may differentially affect pain in women and men. It also addresses the potential clinical implications of pain-augmenting effects of depression in women.

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References

Riley J, Robinson M, Wade J, Myers C, Price D . Sex differences in negative emotional responses to chronic pain. J Pain. 2003; 2(6):354-9. DOI: 10.1054/jpai.2001.27000. View

Poole H, Bramwell R, Murphy P . Factor Structure of the Beck Depression Inventory-II in patients With chronic pain. Clin J Pain. 2006; 22(9):790-8. DOI: 10.1097/01.ajp.0000210930.20322.93. View

Unruh A . Gender variations in clinical pain experience. Pain. 1996; 65(2-3):123-67. DOI: 10.1016/0304-3959(95)00214-6. View

Hirsh A, Waxenberg L, Atchison J, Gremillion H, Robinson M . Evidence for sex differences in the relationships of pain, mood, and disability. J Pain. 2006; 7(8):592-601. DOI: 10.1016/j.jpain.2006.02.006. View

Rajewska J, Rybakowski J . Depression in premenopausal women: gonadal hormones and serotonergic system assessed by D-fenfluramine challenge test. Prog Neuropsychopharmacol Biol Psychiatry. 2003; 27(4):705-9. DOI: 10.1016/S0278-5846(03)00085-X. View

Geisser M, Roth R, Robinson M . Assessing depression among persons with chronic pain using the Center for Epidemiological Studies-Depression Scale and the Beck Depression Inventory: a comparative analysis. Clin J Pain. 1997; 13(2):163-70. DOI: 10.1097/00002508-199706000-00011. View

Currie S, Wang J . Chronic back pain and major depression in the general Canadian population. Pain. 2004; 107(1-2):54-60. DOI: 10.1016/j.pain.2003.09.015. View

Harris C, DEon J . Psychometric properties of the Beck Depression Inventory--second edition (BDI-II) in individuals with chronic pain. Pain. 2007; 137(3):609-622. DOI: 10.1016/j.pain.2007.10.022. View

LeResche L, Mancl L, Sherman J, Gandara B, Dworkin S . Changes in temporomandibular pain and other symptoms across the menstrual cycle. Pain. 2003; 106(3):253-261. DOI: 10.1016/j.pain.2003.06.001. View

10.

Lautenbacher S, Roscher S, Strian D, Fassbender K, Krumrey K, Krieg J . Pain perception in depression: relationships to symptomatology and naloxone-sensitive mechanisms. Psychosom Med. 1994; 56(4):345-52. DOI: 10.1097/00006842-199407000-00010. View

11.

Fillingim R, Ness T . Sex-related hormonal influences on pain and analgesic responses. Neurosci Biobehav Rev. 2000; 24(4):485-501. DOI: 10.1016/s0149-7634(00)00017-8. View

12.

Sullivan M, Adams H, Tripp D, Stanish W . Stage of chronicity and treatment response in patients with musculoskeletal injuries and concurrent symptoms of depression. Pain. 2007; 135(1-2):151-9. DOI: 10.1016/j.pain.2007.05.021. View

13.

Doan B, Wadden N . Relationships between depressive symptoms and descriptions of chronic pain. Pain. 1989; 36(1):75-84. DOI: 10.1016/0304-3959(89)90113-9. View

14.

Schultz I, Crook J, Meloche G, BERKOWITZ J, Milner R, Zuberbier O . Psychosocial factors predictive of occupational low back disability: towards development of a return-to-work model. Pain. 2004; 107(1-2):77-85. DOI: 10.1016/j.pain.2003.09.019. View

15.

Roth R, Geisser M, Theisen-Goodvich M, Dixon P . Cognitive complaints are associated with depression, fatigue, female sex, and pain catastrophizing in patients with chronic pain. Arch Phys Med Rehabil. 2005; 86(6):1147-54. DOI: 10.1016/j.apmr.2004.10.041. View

16.

Kuehner C . Gender differences in unipolar depression: an update of epidemiological findings and possible explanations. Acta Psychiatr Scand. 2003; 108(3):163-74. DOI: 10.1034/j.1600-0447.2003.00204.x. View

17.

Melzack R . The McGill Pain Questionnaire: major properties and scoring methods. Pain. 1975; 1(3):277-299. DOI: 10.1016/0304-3959(75)90044-5. View

18.

Bolton J . Psychological distress and disability in back pain patients: evidence of sex differences. J Psychosom Res. 1994; 38(8):849-58. DOI: 10.1016/0022-3999(94)90072-8. View

19.

Wijnhoven H, de Vet H, Picavet H . Prevalence of musculoskeletal disorders is systematically higher in women than in men. Clin J Pain. 2006; 22(8):717-24. DOI: 10.1097/01.ajp.0000210912.95664.53. View

20.

Nikendei C, Dengler W, Wiedemann G, Pauli P . Selective processing of pain-related word stimuli in subclinical depression as indicated by event-related brain potentials. Biol Psychol. 2005; 70(1):52-60. DOI: 10.1016/j.biopsycho.2004.11.012. View