Primary CNS Lymphoma and HLA Class I and II Alleles in a German Cohort of Immunocompetent Patients

Overview

Journal J Neurooncol

Publisher Springer

Date 2008 Jul 1

PMID 18587537

Citations 2

Authors

Delia Kurzwelly

Claudia A Muller

Agnieszka Korfel

Eckhard Thiel

Michael Linnebank

Michael Weller

Ulrich Herrlinger

Affiliations

Soon will be listed here.

Abstract

Human leukocyte antigens (HLA) are involved in the regulation of immune response to infection and in malignant transformation. Several HLA alleles are associated with immunological or malignant diseases. The aim of the present study was to evaluate a potential association of HLA class I and II alleles with primary central nervous system lymphoma (PCNSL) in immunocompetent patients. We therefore analyzed particular HLA-A, HLA-B and HLA-DRB1 alleles in 82 PCNSL patients and compared the data to those in 327 population controls. No significant difference between these two groups was found using Pearson's chi(2) test. These data do not support the hypothesis that HLA alleles play a major role in the pathogenesis of PCNSL.

Citing Articles

Advances in Pathobiology of Primary Central Nervous System Lymphoma.

Yang X, Liu Y Chin Med J (Engl). 2017; 130(16):1973-1979.

PMID: 28776551 PMC: 5555133. DOI: 10.4103/0366-6999.211879.

Genetic variants of folate and methionine metabolism and PCNSL incidence in a German patient population.

Kurzwelly D, Knop S, Guenther M, Loeffler J, Korfel A, Thiel E J Neurooncol. 2010; 100(2):187-92.

PMID: 20237949 DOI: 10.1007/s11060-010-0154-4.

References

Diepstra A, Niens M, Vellenga E, van Imhoff G, Nolte I, Schaapveld M . Association with HLA class I in Epstein-Barr-virus-positive and with HLA class III in Epstein-Barr-virus-negative Hodgkin's lymphoma. Lancet. 2005; 365(9478):2216-24. DOI: 10.1016/S0140-6736(05)66780-3. View

Phan T, ONeill B, Kurtin P . Posttransplant primary CNS lymphoma. Neuro Oncol. 2001; 2(4):229-38. PMC: 1920594. DOI: 10.1093/neuonc/2.4.229. View

Burt R, Vaughan T, McKnight B, Davis S, Beckmann A, Smith A . Associations between human leukocyte antigen type and nasopharyngeal carcinoma in Caucasians in the United States. Cancer Epidemiol Biomarkers Prev. 1996; 5(11):879-87. View

Chatzipetrou M, Tarassi K, Konstadoulakis M, Pappas H, Zafirellis K, Athanassiades T . Human leukocyte antigens as genetic markers in colorectal carcinoma. Dis Colon Rectum. 1999; 42(1):66-70. DOI: 10.1007/BF02235184. View

Nitta T, Ebato M, Sato K . Association of malignant glioma with the human leukocyte antigen, HLA-A24(9). Neurosurg Rev. 1994; 17(3):211-5. DOI: 10.1007/BF00418435. View

Machulla H, Steinborn F, Tschigrjai M, Langner J, Rainov N . Meningioma: is there an association with human leukocyte antigens?. Cancer Epidemiol Biomarkers Prev. 2003; 12(12):1438-42. View

Forsyth P, DeAngelis L . Biology and management of AIDS-associated primary CNS lymphomas. Hematol Oncol Clin North Am. 1996; 10(5):1125-34. DOI: 10.1016/s0889-8588(05)70388-9. View

Linnebank M, Schmidt S, Kolsch H, Linnebank A, Heun R, Schmidt-Wolf I . The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma. Br J Cancer. 2004; 90(10):1969-71. PMC: 2409477. DOI: 10.1038/sj.bjc.6601777. View

Kotter I, Gunaydin I, Stubiger N, Yazici H, Fresko I, Zouboulis C . Comparative analysis of the association of HLA-B*51 suballeles with Behçet's disease in patients of German and Turkish origin. Tissue Antigens. 2001; 58(3):166-70. DOI: 10.1034/j.1399-0039.2001.580304.x. View

10.

Hodak E, Lapidoth M, KOHN K, David D, Brautbar B, Kfir K . Mycosis fungoides: HLA class II associations among Ashkenazi and non-Ashkenazi Jewish patients. Br J Dermatol. 2002; 145(6):974-80. DOI: 10.1046/j.1365-2133.2001.04496.x. View

11.

Montesinos-Rongen M, Kuppers R, Schluter D, Spieker T, Van Roost D, Schaller C . Primary central nervous system lymphomas are derived from germinal-center B cells and show a preferential usage of the V4-34 gene segment. Am J Pathol. 1999; 155(6):2077-86. PMC: 1866926. DOI: 10.1016/S0002-9440(10)65526-5. View

12.

Machulla H, Steinborn F, Schaaf A, Heidecke V, Rainov N . Brain glioma and human leukocyte antigens (HLA)--is there an association. J Neurooncol. 2001; 52(3):253-61. DOI: 10.1023/a:1010612327647. View

13.

Manns A, Hanchard B, Morgan O, Wilks R, Cranston B, Nam J . Human leukocyte antigen class II alleles associated with human T-cell lymphotropic virus type I infection and adult T-cell leukemia/lymphoma in a Black population. J Natl Cancer Inst. 1998; 90(8):617-22. DOI: 10.1093/jnci/90.8.617. View