DSCAM is a Netrin Receptor That Collaborates with DCC in Mediating Turning Responses to Netrin-1

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2008 Jul 1

PMID 18585357

Citations 145

Authors

Alice Ly

Anatoly Nikolaev

Geetha Suresh

Yufang Zheng

Marc Tessier-Lavigne

Elke Stein

Affiliations

Soon will be listed here.

Abstract

During nervous system development, spinal commissural axons project toward and across the ventral midline. They are guided in part by netrin-1, made by midline cells, which attracts the axons by activating the netrin receptor DCC. However, previous studies suggest that additional receptor components are required. Here, we report that the Down's syndrome Cell Adhesion Molecule (DSCAM), a candidate gene implicated in the mental retardation phenotype of Down's syndrome, is expressed on spinal commissural axons, binds netrin-1, and is necessary for commissural axons to grow toward and across the midline. DSCAM and DCC can each mediate a turning response of these neurons to netrin-1. Similarly, Xenopus spinal neurons exogenously expressing DSCAM can be attracted by netrin-1 independently of DCC. These results show that DSCAM is a receptor that can mediate turning responses to netrin-1 and support a key role for netrin/DSCAM signaling in commissural axon guidance in vertebrates.

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