Non-coding RNAs Take Centre Stage in Epithelial-to-mesenchymal Transition

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2008 Jul 1

PMID 18585040

Citations 65

Authors

Amparo Cano

M Angela Nieto

Affiliations

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Abstract

Noncoding RNAs are emerging as central players in gene expression regulation through the targeting of a plethora of mRNAs. Several recent papers report on the regulation of the epithelial phenotype by the miR-200 (200 family of miRNAs) family and a natural antisense transcript, both acting on the E-cadherin repressors zinc-finger E-box-binding homeobox factors ZEB1 and ZEB2. These findings open new avenues for understanding the modulation of the epithelial-to-mesenchymal transition in physiological and pathological situations.

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