99mTc-HMPAO Labelled White Blood Cell Scintigraphy in Patients with Osteoarticular Infection: the Value of Late Images for Diagnostic Accuracy and Interobserver Reproducibility

Overview

Journal Eur J Clin Microbiol Infect Dis

Publisher Springer

Specialties Infectious Diseases
Microbiology

Date 2008 Jun 28

PMID 18584222

Citations 3

Authors

P Fernandez

A Monet

C Matei

H De Clermont

M Guyot

R Jeandot

H Dutronc

C Dumoulin

M Dupon

D Ducassou

Affiliations

Soon will be listed here.

Abstract

The objectives of this study were to evaluate the diagnostic value of 99mTc-HMPAO labelled white blood cell scintigraphy (WBCS) in patients with suspected osteomyelitis using late images and to study interobserver reproducibility. This study prospectively included 120 patients, and after a follow-up of one year, only 70 patients (n = 49 with implants, n = 21 without implants) were selected. The final diagnosis of infection was based either on microbiological data (n = 54) or follow-up (n = 16). We performed WBCS with 4 h and 24 h scans. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 77%, 72%, 83%, 64%, and 75% at 4 h, and 74%, 87%, 91%, 59%, and 79% at 24 h, respectively. The interobserver reproducibility shows a 63% prevalence of agreement between results (kappa = 0.5) at 4 h and 80% (kappa = 0.74) at 24 h, respectively. WBCS with 24-h images improves specificity and interobserver reproducibility in patients with suspected osteoarticular sepsis.

Citing Articles

Intra and Inter-Rater Variability in the Interpretation of White Blood Cell Scintigraphy of Hip and Knee Prostheses.

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The use of labelled leucocyte scintigraphy to evaluate chronic periprosthetic joint infections: a retrospective multicentre study on 168 patients.

Blanc P, Bonnet E, Giordano G, Monteil J, Salabert A, Payoux P Eur J Clin Microbiol Infect Dis. 2019; 38(9):1625-1631.

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Prosthetic joint infections: radionuclide state-of-the-art imaging.

Gemmel F, Van den Wyngaert H, Love C, Welling M, Gemmel P, Palestro C Eur J Nucl Med Mol Imaging. 2012; 39(5):892-909.

PMID: 22361912 DOI: 10.1007/s00259-012-2062-7.

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