Stop-flow Lithography to Generate Cell-laden Microgel Particles

Overview

Journal Lab Chip

Publisher Royal Society of Chemistry

Specialties Biotechnology
Chemistry

Date 2008 Jun 28

PMID 18584079

Citations 73

Authors

Priyadarshi Panda

Shamsher Ali

Edward Lo

Bong Geun Chung

T Alan Hatton

Ali Khademhosseini

Patrick S Doyle

Affiliations

Soon will be listed here.

Abstract

Encapsulating cells within hydrogels is important for generating three-dimensional (3D) tissue constructs for drug delivery and tissue engineering. This paper describes, for the first time, the fabrication of large numbers of cell-laden microgel particles using a continuous microfluidic process called stop-flow lithography (SFL). Prepolymer solution containing cells was flowed through a microfluidic device and arrays of individual particles were repeatedly defined using pulses of UV light through a transparency mask. Unlike photolithography, SFL can be used to synthesize microgel particles continuously while maintaining control over particle size, shape and anisotropy. Therefore, SFL may become a useful tool for generating cell-laden microgels for various biomedical applications.

Citing Articles

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