Bacterial Infection of Endometrial Stromal Cells Influences Bovine Herpesvirus 4 Immediate Early Gene Activation: a New Insight into Bacterial and Viral Interaction for Uterine Disease

Overview

Journal Reproduction

Specialty Reproductive Medicine

Date 2008 Jun 26

PMID 18577555

Citations 25

Authors

Gaetano Donofrio

Lara Ravanetti

Sandro Cavirani

Shan Herath

Antonio Capocefalo

Iain Martin Sheldon

Affiliations

Soon will be listed here.

Abstract

Experimental infection with the gamma-herpesvirus bovine herpesvirus 4 (BoHV-4) rarely establishes disease, yet BoHV-4 is commonly associated with uterine disease in cattle. Uterine disease involves co-infection with bacteria such as Escherichia coli, which stimulate the production of prostaglandin E(2) (PGE(2)) by endometrial cells. BoHV-4 replication depends on immediate early 2 (IE2) gene transactivation and, in the present study, PGE(2), E. coli or its lipopolysaccharide upregulated the IE2 gene promoter in uterine cells. Bacterial co-infection is important for BoHV-4 uterine disease.

Citing Articles

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Modulation of Apoptosis by Bovine Gammaherpesvirus 4 Infection in Bovine Endometrial Cells and the Possible Role of LPS in This Process.

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Predisposing factors, diagnostic and therapeutic aspects of persistent endometritis in postpartum cows.

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MicroRNA: Could It Play a Role in Bovine Endometritis?.

Umar T, Yin B, Umer S, Ma X, Jiang K, Umar Z Inflammation. 2021; 44(5):1683-1695.

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