Exodus-1 (CCL20): Evidence for the Participation of This Chemokine in Spontaneous Labor at Term, Preterm Labor, and Intrauterine Infection

Overview

Journal J Perinat Med

Date 2008 Jun 26

PMID 18576931

Citations 41

Authors

Neil Hamill

Roberto Romero

Francesca Gotsch

Juan Pedro Kusanovic

Sam Edwin

Offer Erez

Nandor Gabor Than

Pooja Mittal

Jimmy Espinoza

Lara A Friel

Edi Vaisbuch

Shali Mazaki-Tovi

Sonia S Hassan

Affiliations

Soon will be listed here.

Abstract

Aim: CCL20, also known as MIP-3 alpha, is a chemokine that participates in chemotaxis of immature dendritic cells, effector/memory T-cells, and B-lymphocytes. The objectives of this study were to determine whether CCL20 can be detected in amniotic fluid (AF) and if AF concentration of this chemokine changes with advancing gestational age, parturition (term and preterm), and intra-amniotic infection/inflammation (IAI).

Methods: A cross-sectional study was conducted including the following groups: (1) mid-trimester of pregnancy (n=65); (2) term not in labor (TNL; n=22); (3) term in labor (TIL; n=47); (4) spontaneous preterm labor (PTL) who delivered at term (n=57); (5) spontaneous PTL without IAI who delivered preterm (n=71); and (6) spontaneous PTL with IAI (n=38). AF CCL20 concentrations were determined using ELISA.

Results: (1) The median AF CCL20 concentration in TNL was higher than that of mid-trimester patients; (2) Women in spontaneous labor at term had a higher median AF concentration of CCL20 than patients at term not in labor; (3) Patients with spontaneous PTL and IAI had a significantly higher median AF concentration of CCL20 than those without IAI who delivered preterm and those who delivered at term. Moreover, women with spontaneous PTL without IAI who delivered preterm had a significantly higher median AF concentration than those with PTL who subsequently delivered at term.

Conclusions: (1) CCL20 is a physiologic constituent of AF and its concentration increases as term approaches; (2) spontaneous labor (term and preterm) in the absence of IAI is associated with increased bioavailability of AF CCL20 suggesting that an increase in CCL20 is part of the common pathway of human parturition; (3) patients with IAI had dramatic elevations in the AF CCL20 concentrations suggesting that this chemokine participates in the host response to infection or other stimuli associated with intra-amniotic infection.

Citing Articles

Clinical chorioamnionitis at term is characterized by changes in the plasma concentration of CHCHD2/MNRR1, a mitochondrial protein.

Bosco M, Romero R, Gallo D, Suksai M, Gotsch F, Jung E J Matern Fetal Neonatal Med. 2023; 36(2):2222333.

PMID: 37349086 PMC: 10445405. DOI: 10.1080/14767058.2023.2222333.

Amnion-derived serum amyloid A1 participates in sterile inflammation of fetal membranes at parturition.

Lin Y, Zhang F, Lei W, Gan X, Li M, Pan F Inflamm Res. 2023; 72(4):797-812.

PMID: 36879064 DOI: 10.1007/s00011-023-01713-3.

The amniotic fluid proteome changes with term labor and informs biomarker discovery in maternal plasma.

Bhatti G, Romero R, Gomez-Lopez N, Chaiworapongsa T, Than N, Theis K Sci Rep. 2023; 13(1):3136.

PMID: 36823217 PMC: 9950459. DOI: 10.1038/s41598-023-28157-3.

Chronic Venous Disease during Pregnancy Causes a Systematic Increase in Maternal and Fetal Proinflammatory Markers.

Ortega M, Gomez-Lahoz A, Sanchez-Trujillo L, Fraile-Martinez O, Garcia-Montero C, Guijarro L Int J Mol Sci. 2022; 23(16).

PMID: 36012236 PMC: 9409364. DOI: 10.3390/ijms23168976.

Regulation and Function of Chemokines at the Maternal-Fetal Interface.

Zhang S, Ding J, Zhang Y, Liu S, Yang J, Yin T Front Cell Dev Biol. 2022; 10:826053.

PMID: 35938162 PMC: 9354654. DOI: 10.3389/fcell.2022.826053.

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