Actions of Human Telomerase Beyond Telomeres

Overview

Journal Cell Res

Specialty Cell Biology

Date 2008 Jun 25

PMID 18574498

Citations 94

Authors

Yusheng Cong

Jerry W Shay

Affiliations

Soon will be listed here.

Abstract

Telomerase has fundamental roles in bypassing cellular aging and in cancer progression by maintaining telomere homeostasis and integrity. However, recent studies have led some investigators to suggest novel biochemical properties of telomerase in several essential cell signaling pathways without apparent involvement of its well established function in telomere maintenance. These observations may further enhance our understanding of the molecular actions of telomerase in aging and cancer. This review will provide an update on the extracurricular activities of telomerase in apoptosis, DNA repair, stem cell function, and in the regulation of gene expression.

Citing Articles

Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity.

Machitani M, Nomura A, Yamashita T, Yasukawa M, Ueki S, Fujita K Nat Cell Biol. 2024; 26(6):932-945.

PMID: 38806647 DOI: 10.1038/s41556-024-01427-6.

TERC promotes non-small cell lung cancer progression by facilitating the nuclear localization of TERT.

Sun H, Li X, Long Q, Wang X, Zhu W, Chen E iScience. 2024; 27(6):109869.

PMID: 38799568 PMC: 11126826. DOI: 10.1016/j.isci.2024.109869.

Telomerase RNA-based aptamers restore defective myelopoiesis in congenital neutropenic syndromes.

Martinez-Balsalobre E, Garcia-Castillo J, Garcia-Moreno D, Naranjo-Sanchez E, Fernandez-Lajarin M, Blasco M Nat Commun. 2023; 14(1):5912.

PMID: 37737237 PMC: 10516865. DOI: 10.1038/s41467-023-41472-7.

The hTERT-p50 homodimer inhibits PLEKHA7 expression to promote gastric cancer invasion and metastasis.

Wu Y, Xiao Y, Tian L, He B, Liu J, Li Z Oncogene. 2023; 42(14):1144-1156.

PMID: 36823376 PMC: 10063444. DOI: 10.1038/s41388-023-02630-9.

hTERT Downregulation Attenuates Resistance to DOX, Impairs FAK-Mediated Adhesion, and Leads to Autophagy Induction in Breast Cancer Cells.

Romaniuk-Drapala A, Toton E, Konieczna N, Machnik M, Barczak W, Kowal D Cells. 2021; 10(4).

PMID: 33920284 PMC: 8068966. DOI: 10.3390/cells10040867.