The Use of Ultrasound and Micelles in Cancer Treatment

Overview

Journal J Nanosci Nanotechnol

Publisher American Scientific Publishers

Specialty Biotechnology

Date 2008 Jun 25

PMID 18572632

Citations 17

Authors

Ghaleb A Husseini

William G Pitt

Affiliations

Soon will be listed here.

Abstract

The high toxicity of potent chemotherapeutic drugs like Doxorubicin (Dox) limits the therapeutic window in which they can be applied. This window can be expanded by controlling the drug delivery in both space and time such that non-targeted tissues are not adversely affected. Recent research has shown that ultrasound (US) can be used to control the release of Dox and other hydrophobic drugs from polymeric micelles in both time and space. It has also been shown using an in vivo rat tumor model that Dox activity can be enhanced by ultrasound in one region, while in an adjacent region there is little or no effect of the drug. In this article, we review the in vivo and in vitro research being conducted in the area of using ultrasound to enhance and target micellar drug delivery to cancerous tissues. Additionally, we summarize our previously published mathematical models that attempt to represent the release and re-encapsulation phenomena of Dox from Pluronic P105 micelles upon the application of ultrasound. The potential benefits of such controlled chemotherapy compels a thorough investigation of the role of ultrasound (US) and the mechanisms by which US accomplishes drug release and/or enhances drug potency. Therefore we will summarize our findings related to the mechanism involved in acoustically activated micellar drug delivery to tumors.

Citing Articles

Low-Frequency Sonophoresis: A Promising Strategy for Enhanced Transdermal Delivery.

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Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems.

Abuwatfa W, Awad N, Pitt W, Husseini G Polymers (Basel). 2022; 14(5).

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Ultrasound-Responsive Materials for Drug/Gene Delivery.

Cai X, Jiang Y, Lin M, Zhang J, Guo H, Yang F Front Pharmacol. 2020; 10:1650.

PMID: 32082157 PMC: 7005489. DOI: 10.3389/fphar.2019.01650.

A Review of Thermo- and Ultrasound-Responsive Polymeric Systems for Delivery of Chemotherapeutic Agents.

Zardad A, Choonara Y, du Toit L, Kumar P, Mabrouk M, Kondiah P Polymers (Basel). 2019; 8(10).

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Low-Intensity Ultrasound-Induced Anti-inflammatory Effects Are Mediated by Several New Mechanisms Including Gene Induction, Immunosuppressor Cell Promotion, and Enhancement of Exosome Biogenesis and Docking.

Yang Q, Nanayakkara G, Drummer C, Sun Y, Johnson C, Cueto R Front Physiol. 2017; 8:818.

PMID: 29109687 PMC: 5660123. DOI: 10.3389/fphys.2017.00818.

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