"Nought May Endure but Mutability": Spliceosome Dynamics and the Regulation of Splicing

Overview

Journal Mol Cell

Publisher Cell Press

Specialty Cell Biology

Date 2008 Jun 24

PMID 18570869

Citations 88

Authors

Duncan J Smith

Charles C Query

Maria M Konarska

Affiliations

Soon will be listed here.

Abstract

The spliceosome is both compositionally and conformationally dynamic. Each transition along the splicing pathway presents an opportunity for progression, pausing, or discard, allowing splice site choice to be regulated throughout both the assembly and catalytic phases of the reaction.

Citing Articles

Conserved intronic secondary structures with concealed branch sites regulate alternative splicing of poison exons.

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Programmable RNA writing with trans-splicing.

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Visualizing group II intron dynamics between the first and second steps of splicing.

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