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Circulating Survivin Indicates Severe Course of Juvenile Idiopathic Arthritis

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Specialty Rheumatology
Date 2008 Jun 21
PMID 18565266
Citations 9
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Abstract

Background: Survivin is an anti-apoptotic protein that has been recently suggested as a predictive marker of joint destruction in adult rheumatoid arthritis. We assessed the presence of extracellular survivin in patients with juvenile idiopathic arthritis (JIA).

Methods: Survivin levels were assessed in the circulation of 46 patients with JIA and in the age- and gender-matched controls (n=46) having no inflammatory disease, by ELISA. Survivin levels were analyzed with respect to the onset type and the activity of the joint disease. The intensity of inflammation and cartilage turnover was measured as levels of IL-6, serum amyloid A protein (SAA), and cartilage oligomeric matrix protein (COMP), respectively.

Results: The levels of extracellular survivin were significantly higher in JIA compared to the controls (p=0.0002). High levels of survivin (above mean + 2SD of the controls) were detected in 8/46 (17% JIA patients. High survivin expression was associated with polyarticular onset, active phase of arthritis. In contrast, survivin was neither related to the levels of IL-6, SAA, nor to COMP.

Conclusion: Circulating survivin is expressed in a significant group of patients with JIA being associated to a severe course of the disease. It may be potentially used to select children with unfavorable prognosis of JIA who are in need of active pharmacologic treatment.

Citing Articles

The Behaviour of Serum Survivin in Patients With Lupus Nephritis.

Lisboa R, de Oliveira F, Quaresma T, de Almeida R, Oliveira R, Junior P Biomark Insights. 2022; 17:11772719221131470.

PMID: 36311208 PMC: 9597205. DOI: 10.1177/11772719221131470.


Dysregulation of Survivin-Targeting microRNAs in Autoimmune Diseases: New Perspectives for Novel Therapies.

Shomali N, Maashi M, Baradaran B, Daei Sorkhabi A, Sarkesh A, Mohammadi H Front Immunol. 2022; 13:839945.

PMID: 35309327 PMC: 8927965. DOI: 10.3389/fimmu.2022.839945.


Concentration of survivin in children with oligo- and polyarticular juvenile idiopathic arthritis (JIA): diagnostic and prognostic value-a single-center study.

Lipinska J, Kaszkowiak M, Malachowska B, Swidrowska-Jaros J, Smolewska E Arthritis Res Ther. 2021; 23(1):40.

PMID: 33494811 PMC: 7836505. DOI: 10.1186/s13075-021-02424-y.


Exosomal survivin facilitates vesicle internalization.

Gonda A, Kabagwira J, Senthil G, Ferguson Bennit H, Neidigh J, Khan S Oncotarget. 2018; 9(79):34919-34934.

PMID: 30405884 PMC: 6201849. DOI: 10.18632/oncotarget.26182.


Survivin, a key player in cancer progression, increases in obesity and protects adipose tissue stem cells from apoptosis.

Ejarque M, Ceperuelo-Mallafre V, Serena C, Pachon G, Nunez-Alvarez Y, Terron-Puig M Cell Death Dis. 2017; 8(5):e2802.

PMID: 28518147 PMC: 5520726. DOI: 10.1038/cddis.2017.209.