Asperger Syndrome

Overview

Journal Eur Child Adolesc Psychiatry

Specialties Pediatrics
Psychiatry

Date 2008 Jun 20

PMID 18563474

Citations 13

Authors

Marc R Woodbury-Smith

Fred R Volkmar

Affiliations

Soon will be listed here.

Abstract

Asperger syndrome (AS) is a chronic neurodevelopmental disorder of social interaction, communication, and a restricted range of behaviors or interests. Although not generally associated with intellectual disability, the severe social disability and, in many cases, associated mental health and other medical problems, result in disability throughout life. The diagnosis is often delayed, sometimes into adulthood, which is unfortunate because there are now a range of interventions available, and the current evidence supports intervention starting as early in childhood as possible. The aim of this review is to present a description of AS, an up to date synopsis of the literature pertaining to its etiology, co-morbidity and intervention options, and a discussion of current nosological controversies.

Citing Articles

Review of the Brain's Behaviour after Injury and Disease for Its Application in an Agent-Based Model (ABM).

Irastorza-Valera L, Soria-Gomez E, Benitez J, Montans F, Saucedo-Mora L Biomimetics (Basel). 2024; 9(6).

PMID: 38921242 PMC: 11202129. DOI: 10.3390/biomimetics9060362.

Autism spectrum disorder and personality disorders: Comorbidity and differential diagnosis.

Rinaldi C, Attanasio M, Valenti M, Mazza M, Keller R World J Psychiatry. 2022; 11(12):1366-1386.

PMID: 35070783 PMC: 8717043. DOI: 10.5498/wjp.v11.i12.1366.

Subtyping the Autism Spectrum Disorder: Comparison of Children with High Functioning Autism and Asperger Syndrome.

de Giambattista C, Ventura P, Trerotoli P, Margari M, Palumbi R, Margari L J Autism Dev Disord. 2018; 49(1):138-150.

PMID: 30043350 PMC: 6331497. DOI: 10.1007/s10803-018-3689-4.

Perspective-taking is two-sided: Misunderstandings between people with Asperger's syndrome and their family members.

Heasman B, Gillespie A Autism. 2017; 22(6):740-750.

PMID: 28683569 PMC: 6055325. DOI: 10.1177/1362361317708287.

Inter-individual cognitive variability in children with Asperger's syndrome.

Gonzalez-Gadea M, Tripicchio P, Rattazzi A, Baez S, Marino J, Roca M Front Hum Neurosci. 2014; 8:575.

PMID: 25132817 PMC: 4117184. DOI: 10.3389/fnhum.2014.00575.

References

Gillberg C, Rastam M, Wentz E . The Asperger Syndrome (and high-functioning autism) Diagnostic Interview (ASDI): a preliminary study of a new structured clinical interview. Autism. 2001; 5(1):57-66. DOI: 10.1177/1362361301005001006. View

Kwon H, Ow A, Pedatella K, Lotspeich L, Reiss A . Voxel-based morphometry elucidates structural neuroanatomy of high-functioning autism and Asperger syndrome. Dev Med Child Neurol. 2004; 46(11):760-4. DOI: 10.1017/s0012162204001306. View

McCracken J, McGough J, Shah B, Cronin P, Hong D, Aman M . Risperidone in children with autism and serious behavioral problems. N Engl J Med. 2002; 347(5):314-21. DOI: 10.1056/NEJMoa013171. View

Schultz R, Gauthier I, Klin A, Fulbright R, Anderson A, Volkmar F . Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome. Arch Gen Psychiatry. 2000; 57(4):331-40. DOI: 10.1001/archpsyc.57.4.331. View

Ring H, Woodbury-Smith M, Watson P, Wheelwright S, Baron-Cohen S . Clinical heterogeneity among people with high functioning autism spectrum conditions: evidence favouring a continuous severity gradient. Behav Brain Funct. 2008; 4:11. PMC: 2265729. DOI: 10.1186/1744-9081-4-11. View

Hippler K, Klicpera C . A retrospective analysis of the clinical case records of 'autistic psychopaths' diagnosed by Hans Asperger and his team at the University Children's Hospital, Vienna. Philos Trans R Soc Lond B Biol Sci. 2003; 358(1430):291-301. PMC: 1693115. DOI: 10.1098/rstb.2002.1197. View

Lord C, Rutter M, Le Couteur A . Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord. 1994; 24(5):659-85. DOI: 10.1007/BF02172145. View

Bauman M, Kemper T . Histoanatomic observations of the brain in early infantile autism. Neurology. 1985; 35(6):866-74. DOI: 10.1212/wnl.35.6.866. View

Seltzer M, Krauss M, Shattuck P, Orsmond G, Swe A, Lord C . The symptoms of autism spectrum disorders in adolescence and adulthood. J Autism Dev Disord. 2004; 33(6):565-81. DOI: 10.1023/b:jadd.0000005995.02453.0b. View

10.

Ehlers S, Gillberg C . The epidemiology of Asperger syndrome. A total population study. J Child Psychol Psychiatry. 1993; 34(8):1327-50. DOI: 10.1111/j.1469-7610.1993.tb02094.x. View

11.

Ehlers S, Gillberg C, Wing L . A screening questionnaire for Asperger syndrome and other high-functioning autism spectrum disorders in school age children. J Autism Dev Disord. 1999; 29(2):129-41. DOI: 10.1023/a:1023040610384. View

12.

Courchesne E, Townsend J, Saitoh O . The brain in infantile autism: posterior fossa structures are abnormal. Neurology. 1994; 44(2):214-23. DOI: 10.1212/wnl.44.2.214. View

13.

Spiker D, Lotspeich L, DiMiceli S, Myers R, Risch N . Behavioral phenotypic variation in autism multiplex families: evidence for a continuous severity gradient. Am J Med Genet. 2002; 114(2):129-36. DOI: 10.1002/ajmg.10188. View

14.

Ghaziuddin M . Defining the behavioral phenotype of Asperger syndrome. J Autism Dev Disord. 2007; 38(1):138-42. DOI: 10.1007/s10803-007-0371-7. View

15.

Lord C, Risi S, Lambrecht L, Cook Jr E, Leventhal B, DiLavore P . The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord. 2000; 30(3):205-23. View

16.

Namerow L, Thomas P, Bostic J, Prince J, Monuteaux M . Use of citalopram in pervasive developmental disorders. J Dev Behav Pediatr. 2003; 24(2):104-8. DOI: 10.1097/00004703-200304000-00005. View

17.

Volkmar F, Klin A, Schultz R, Bronen R, Marans W, Sparrow S . Asperger's syndrome. J Am Acad Child Adolesc Psychiatry. 1996; 35(1):118-23. DOI: 10.1097/00004583-199601000-00020. View

18.

Miller J, Ozonoff S . The external validity of Asperger disorder: lack of evidence from the domain of neuropsychology. J Abnorm Psychol. 2000; 109(2):227-38. View

19.

Veenstra-VanderWeele J, Cook Jr E . Molecular genetics of autism spectrum disorder. Mol Psychiatry. 2004; 9(9):819-32. DOI: 10.1038/sj.mp.4001505. View

20.

Lainhart J, Piven J, Wzorek M, Landa R, Santangelo S, Coon H . Macrocephaly in children and adults with autism. J Am Acad Child Adolesc Psychiatry. 1997; 36(2):282-90. DOI: 10.1097/00004583-199702000-00019. View