Serotonin Type 1D Receptors (5HTR) Are Differentially Distributed in Nerve Fibres Innervating Craniofacial Tissues

Overview

Journal Cephalalgia

Specialties Neurology
Psychiatry

Date 2008 Jun 19

PMID 18557979

Citations 24

Authors

A M Harriott

M S Gold

Affiliations

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Abstract

We tested the hypothesis that the 5HT(1D)R, the primary antinociceptive target of triptans, is differentially distributed in tissues responsible for migraine pain. The density of 5HT(1D)R was quantified in tissues obtained from adult female rats with Western blot analysis. Receptor location was assessed with immunohistochemistry. The density of 5HT(1D)R was significantly greater in tissues known to produce migraine-like pain (i.e. circle of Willis and dura) than in structures in which triptans have no antinociceptive efficacy (i.e. temporalis muscle). 5HT(1D)R-like immunoreactivity was restricted to neuronal fibres, where it colocalized with calcitonin gene-related peptide and tyrosine hydroxylase immunoreactive fibres. These results are consistent with our hypothesis that the limited therapeutic profile of triptans could reflect its differential peripheral distribution and that the antinociceptive efficacy reflects inhibition of neuropeptide release from sensory afferents. An additional site of action at sympathetic efferents is also suggested.

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References

Strassman A, Raymond S, Burstein R . Sensitization of meningeal sensory neurons and the origin of headaches. Nature. 1996; 384(6609):560-4. DOI: 10.1038/384560a0. View

Burstein R, Jakubowski M . Analgesic triptan action in an animal model of intracranial pain: a race against the development of central sensitization. Ann Neurol. 2004; 55(1):27-36. DOI: 10.1002/ana.10785. View

Hou M, Kanje M, Longmore J, Tajti J, Uddman R, Edvinsson L . 5-HT(1B) and 5-HT(1D) receptors in the human trigeminal ganglion: co-localization with calcitonin gene-related peptide, substance P and nitric oxide synthase. Brain Res. 2001; 909(1-2):112-20. DOI: 10.1016/s0006-8993(01)02645-2. View

Bouchelet I, Cohen Z, Case B, Seguela P, Hamel E . Differential expression of sumatriptan-sensitive 5-hydroxytryptamine receptors in human trigeminal ganglia and cerebral blood vessels. Mol Pharmacol. 1996; 50(2):219-23. View

Provitera V, Nolano M, Pagano A, Caporaso G, Stancanelli A, Santoro L . Myelinated nerve endings in human skin. Muscle Nerve. 2007; 35(6):767-75. DOI: 10.1002/mus.20771. View

Vega J, Amenta F, Hernandez L, Del Valle M . Presence of catecholamine-related enzymes in a subpopulation of primary sensory neurons in dorsal root ganglia of the rat. Cell Mol Biol. 1991; 37(5):519-30. View

Buzzi M, Carter W, Shimizu T, Heath 3rd H, Moskowitz M . Dihydroergotamine and sumatriptan attenuate levels of CGRP in plasma in rat superior sagittal sinus during electrical stimulation of the trigeminal ganglion. Neuropharmacology. 1991; 30(11):1193-200. DOI: 10.1016/0028-3908(91)90165-8. View

Olesen J, Friberg L, Olsen T, Iversen H, Lassen N, Andersen A . Timing and topography of cerebral blood flow, aura, and headache during migraine attacks. Ann Neurol. 1990; 28(6):791-8. DOI: 10.1002/ana.410280610. View

Moran A, Fernandez M, Velasco C, Martin M, San Roman L . Characterization of prejunctional 5-HT1 receptors that mediate the inhibition of pressor effects elicited by sympathetic stimulation in the pithed rat. Br J Pharmacol. 1998; 123(6):1205-13. PMC: 1565267. DOI: 10.1038/sj.bjp.0701714. View

10.

Levy D, Jakubowski M, Burstein R . Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT 1B/1D receptor agonists. Proc Natl Acad Sci U S A. 2004; 101(12):4274-9. PMC: 384731. DOI: 10.1073/pnas.0306147101. View

11.

Wurch T, Palmier C, Colpaert F, Pauwels P . Sequence and functional analysis of cloned guinea pig and rat serotonin 5-HT1D receptors: common pharmacological features within the 5-HT1D receptor subfamily. J Neurochem. 1997; 68(1):410-8. DOI: 10.1046/j.1471-4159.1997.68010410.x. View

12.

Kayser V, Aubel B, Hamon M, Bourgoin S . The antimigraine 5-HT 1B/1D receptor agonists, sumatriptan, zolmitriptan and dihydroergotamine, attenuate pain-related behaviour in a rat model of trigeminal neuropathic pain. Br J Pharmacol. 2002; 137(8):1287-97. PMC: 1573605. DOI: 10.1038/sj.bjp.0704979. View

13.

Coderre T, Basbaum A, Levine J . Neural control of vascular permeability: interactions between primary afferents, mast cells, and sympathetic efferents. J Neurophysiol. 1989; 62(1):48-58. DOI: 10.1152/jn.1989.62.1.48. View

14.

Dao T, Lund J, Remillard G, Lavigne G . Is myofascial pain of the temporal muscles relieved by oral sumatriptan? A cross-over pilot study. Pain. 1995; 62(2):241-244. DOI: 10.1016/0304-3959(95)00025-N. View

15.

Brumovsky P, Villar M, Hokfelt T . Tyrosine hydroxylase is expressed in a subpopulation of small dorsal root ganglion neurons in the adult mouse. Exp Neurol. 2006; 200(1):153-65. DOI: 10.1016/j.expneurol.2006.01.023. View

16.

Goadsby P, Edvinsson L . The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats. Ann Neurol. 1993; 33(1):48-56. DOI: 10.1002/ana.410330109. View

17.

Harrison S, Balawi S, Feinmann C, Harris M . Atypical facial pain: a double-blind placebo-controlled crossover pilot study of subcutaneous sumatriptan. Eur Neuropsychopharmacol. 1997; 7(2):83-8. DOI: 10.1016/s0924-977x(96)00385-9. View

18.

Limmroth V, Katsarava Z, Liedert B, Guehring H, Schmitz K, Diener H . An in vivo rat model to study calcitonin gene related peptide release following activation of the trigeminal vascular system. Pain. 2001; 92(1-2):101-6. DOI: 10.1016/s0304-3959(00)00475-9. View

19.

Green P, Basbaum A, Helms C, Levine J . Purinergic regulation of bradykinin-induced plasma extravasation and adjuvant-induced arthritis in the rat. Proc Natl Acad Sci U S A. 1991; 88(10):4162-5. PMC: 51618. DOI: 10.1073/pnas.88.10.4162. View

20.

Zhu B, Blessing W, Gibbins I . Parasympathetic innervation of cephalic arteries in rabbits: comparison with sympathetic and sensory innervation. J Comp Neurol. 1997; 389(3):484-95. DOI: 10.1002/(sici)1096-9861(19971222)389:3<484::aid-cne9>3.0.co;2-x. View