Biochemical Individuality Reflected in Chromatographic, Electrophoretic and Mass-spectrometric Profiles

Overview

Journal J Chromatogr B Analyt Technol Biomed Life Sci

Publisher Elsevier

Specialties Biomedical Engineering
Chemistry

Date 2008 Jun 14

PMID 18551752

Citations 3

Authors

Milos V Novotny

Helena A Soini

Yehia Mechref

Affiliations

Soon will be listed here.

Abstract

This review discusses the current trends in molecular profiling for the emerging systems biology applications. Historically, the methodological developments in separation science were coincident with the availability of new ionization techniques in mass spectrometry. Coupling miniaturized separation techniques with technologically-advanced MS instrumentation and the modern data processing capabilities are at the heart of current platforms for proteomics, glycomics and metabolomics. These are being featured here by the examples from quantitative proteomics, glycan mapping and metabolomic profiling of physiological fluids.

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