Central Mechanism of Action of Antimigraine Prophylactic Drugs

Overview

Journal Neurol Sci

Specialty Neurology

Date 2008 Jul 17

PMID 18545912

Citations 9

Authors

Gerardo Casucci

Veronica Villani

Fabio Frediani

Affiliations

Soon will be listed here.

Abstract

The pathogenesis of migraine is obscure. A hyperexcitable brain state has been postulated. Cortical spreading depression (CSD) is the most suggestive argument for the brain hyperexcitability. It has been showed that valproate, topiramate, amitriptyline and propranolol inhibit CSD in rats, which suggests that most preventative treatments of migraine act by normalising neuronal firing and increasing a genetically lowered and environmentally modified threshold for neuronal discharge. It has also been suggested that some antimigraine prophylactic drugs (i.e., amitriptyline, candesartan and magnesium) may act by restoring central nociceptive dysmodulation.

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