Relationship Between Rectal Sensitivity, Symptoms Intensity and Quality of Life in Patients with Irritable Bowel Syndrome

Overview

Journal Aliment Pharmacol Ther

Specialties Gastroenterology
Pharmacology

Date 2008 Jun 12

PMID 18544074

Citations 17

Authors

J-M Sabate

M Veyrac

F Mion

L Siproudhis

P Ducrotte

F Zerbib

J-C Grimaud

M Dapoigny

F Dyard

B Coffin

Affiliations

Soon will be listed here.

Abstract

Background: Relationships between pain threshold during rectal distension and both symptoms intensity and alteration in quality of life (QoL) in irritable bowel syndrome (IBS) patients have been poorly evaluated.

Aim: To evaluate relationships between rectal sensitivity, IBS symptom intensity and QoL in a multicentre prospective study.

Methods: Rectal threshold for moderate pain was measured during rectal distension in IBS patients (Rome II), while IBS symptoms intensity was assessed by a validated questionnaire and QoL by the Functional Digestive Disorder Quality of Life questionnaire.

Results: Sixty-eight patients (44.2 +/- 12.7 years, 48 women) were included. The mean rectal distending volume for moderate pain was 127 +/- 35 mL while 45 patients (66%) had rectal hypersensitivity (pain threshold <140 mL). Rectal threshold was not significantly related either to overall IBS intensity score (r = -0.66, P = 0.62) or to its different components, or to FDDQL score (r = 0.30, P = 0.14). Among FDDQL domains, only anxiety (r = 0.30, P = 0.01) and coping (r = 0.31, P = 0.009) were significantly related with pain threshold.

Conclusions: In this study, two-thirds of IBS patients exhibited rectal hypersensitivity. No significant correlation was found between rectal threshold and either symptom intensity or alteration in QoL.

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