Dendritic Cells As Immune Regulators: the Mouse Model

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2008 Jun 12

PMID 18544050

Citations 8

Authors

K L Griffiths

H C ONeill

Affiliations

Soon will be listed here.

Abstract

Dendritic cells (DC) are central to the immune system because of their role in antigen presentation leading to either tolerance or immunity among cells of the adaptive immune response. It is becoming increasingly evident that DC show extensive plasticity in terms of their origin and function, giving rise to a number of subsets represented differentially in all lymphoid organs. This article considers the tolerogenic capacity of murine DC and draws a distinction between DC that induce tolerance in the immature state and immunity in an inflammatory context, and those that act as regulatory cells inducing immunosuppression in the presence of inflammation.

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References

Leon B, Lopez-Bravo M, Ardavin C . Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania. Immunity. 2007; 26(4):519-31. DOI: 10.1016/j.immuni.2007.01.017. View

Colonna M, Trinchieri G, Liu Y . Plasmacytoid dendritic cells in immunity. Nat Immunol. 2004; 5(12):1219-26. DOI: 10.1038/ni1141. View

Pooley J, Heath W, Shortman K . Cutting edge: intravenous soluble antigen is presented to CD4 T cells by CD8- dendritic cells, but cross-presented to CD8 T cells by CD8+ dendritic cells. J Immunol. 2001; 166(9):5327-30. DOI: 10.4049/jimmunol.166.9.5327. View

Svensson M, Maroof A, Ato M, Kaye P . Stromal cells direct local differentiation of regulatory dendritic cells. Immunity. 2004; 21(6):805-16. DOI: 10.1016/j.immuni.2004.10.012. View

Tang H, Guo Z, Zhang M, Wang J, Chen G, Cao X . Endothelial stroma programs hematopoietic stem cells to differentiate into regulatory dendritic cells through IL-10. Blood. 2006; 108(4):1189-97. DOI: 10.1182/blood-2006-01-007187. View

Kalinski P, Schuitemaker J, Hilkens C, Kapsenberg M . Prostaglandin E2 induces the final maturation of IL-12-deficient CD1a+CD83+ dendritic cells: the levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation. J Immunol. 1998; 161(6):2804-9. View

Mebius R, Kraal G . Structure and function of the spleen. Nat Rev Immunol. 2005; 5(8):606-16. DOI: 10.1038/nri1669. View

Shortman K, Naik S . Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol. 2006; 7(1):19-30. DOI: 10.1038/nri1996. View

Ginhoux F, Tacke F, Angeli V, Bogunovic M, Loubeau M, Dai X . Langerhans cells arise from monocytes in vivo. Nat Immunol. 2006; 7(3):265-73. PMC: 4727824. DOI: 10.1038/ni1307. View

10.

Onai N, Obata-Onai A, Schmid M, Ohteki T, Jarrossay D, Manz M . Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol. 2007; 8(11):1207-16. DOI: 10.1038/ni1518. View

11.

Hubert P, Jacobs N, Caberg J, Boniver J, Delvenne P . The cross-talk between dendritic and regulatory T cells: good or evil?. J Leukoc Biol. 2007; 82(4):781-94. DOI: 10.1189/jlb.1106694. View

12.

Serafini P, De Santo C, Marigo I, Cingarlini S, Dolcetti L, Gallina G . Derangement of immune responses by myeloid suppressor cells. Cancer Immunol Immunother. 2003; 53(2):64-72. PMC: 11032848. DOI: 10.1007/s00262-003-0443-2. View

13.

Naik S, Metcalf D, Van Nieuwenhuijze A, Wicks I, Wu L, OKeeffe M . Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat Immunol. 2006; 7(6):663-71. DOI: 10.1038/ni1340. View

14.

Cools N, Ponsaerts P, Van Tendeloo V, Berneman Z . Balancing between immunity and tolerance: an interplay between dendritic cells, regulatory T cells, and effector T cells. J Leukoc Biol. 2007; 82(6):1365-74. DOI: 10.1189/jlb.0307166. View

15.

Wilson N, Villadangos J . Regulation of antigen presentation and cross-presentation in the dendritic cell network: facts, hypothesis, and immunological implications. Adv Immunol. 2005; 86:241-305. DOI: 10.1016/S0065-2776(04)86007-3. View

16.

Steinman R, Hawiger D, Nussenzweig M . Tolerogenic dendritic cells. Annu Rev Immunol. 2003; 21:685-711. DOI: 10.1146/annurev.immunol.21.120601.141040. View

17.

Quah B, ONeill H . Maturation of function in dendritic cells for tolerance and immunity. J Cell Mol Med. 2005; 9(3):643-54. PMC: 6741309. DOI: 10.1111/j.1582-4934.2005.tb00494.x. View

18.

van Duivenvoorde L, van Mierlo G, Boonman Z, Toes R . Dendritic cells: vehicles for tolerance induction and prevention of autoimmune diseases. Immunobiology. 2006; 211(6-8):627-32. DOI: 10.1016/j.imbio.2006.05.014. View

19.

ONeill H, Wilson H, Quah B, Abbey J, Despars G, Ni K . Dendritic cell development in long-term spleen stromal cultures. Stem Cells. 2004; 22(4):475-86. DOI: 10.1634/stemcells.22-4-475. View

20.

Makarenkova V, Bansal V, Matta B, Perez L, Ochoa J . CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress. J Immunol. 2006; 176(4):2085-94. DOI: 10.4049/jimmunol.176.4.2085. View