Image-guided Liver Mapping Using Fluorescence Navigation System with Indocyanine Green for Anatomical Hepatic Resection

Overview

Journal World J Surg

Publisher Wiley

Specialty General Surgery

Date 2008 Jun 11

PMID 18543027

Citations 91

Authors

Takeshi Aoki

Daisuke Yasuda

Yoshinori Shimizu

Masanori Odaira

Takashi Niiya

Tomokazu Kusano

Keitaro Mitamura

Ken Hayashi

Noriyuki Murai

Tomotake Koizumi

Hirohisa Kato

Yuta Enami

Mitsuharu Miwa

Mitsuo Kusano

Affiliations

Soon will be listed here.

Abstract

Background: In malignant hepatic neoplasm, anatomic resection could improve survival and limit complications from hepatectomy. Our purpose was to develop an intraoperative method for identifying segment and subsegment of the liver with high-sensitivity near-infrared fluorescence imaging.

Methods: The subjects were 35 patients with hepatic malignant liver disease who received hepatectomy in 2006. The segments of liver method of identification that used infrared observation camera system termed Photo Dynamic Eye-2 (PDE-2) with indocianine green (ICG) for the patient with malignant liver tumor (hepatocellular carcinoma: 13 cases; metastatic liver cancer: 18 cases; intrahepatic cholangio carcinoma: 4 cases) were performed before liver resection.

Results: Although greenish stain of the liver surface after the injection of ICG via portal vein is not visible clearly without infrared observation camera system PDE-2, 1 minute after injection of ICG with fluorescent using infrared observation camera system PDE-2, demarcation of liver segment and subsegment was clearly detected. Ten minutes after injection of ICG with fluorescent using infrared observation camera system PDE-2, fluorescence of liver subsegment remained. Stained subsegment and segment of liver were identifiable in 33 (94.3%) of the 35 patients. There were no complications or side-effects related to the injection of patent blue dye.

Conclusion: We demonstrated here that near-infrared fluorescence imaging system is a novel and reliable intraoperative technique to identify hepatic segment and subsegment for anatomical hepatic resection.

Citing Articles

Real-Time Navigation in Liver Surgery Through Indocyanine Green Fluorescence: An Updated Analysis of Worldwide Protocols and Applications.

Avella P, Spiezia S, Rotondo M, Cappuccio M, Scacchi A, Inglese G Cancers (Basel). 2025; 17(5).

PMID: 40075718 PMC: 11898688. DOI: 10.3390/cancers17050872.

Real-Time Blood Flow Assessment Using ICG Fluorescence Imaging During Hepatobiliary and Pancreatic Surgery with Consideration of Vascular Reconstruction.

Fujimoto H, Kinoshita M, Ahn C, Yasuda T, Hatta K, Yoshida M Cancers (Basel). 2025; 17(5).

PMID: 40075714 PMC: 11899419. DOI: 10.3390/cancers17050868.

Laparoscopic Anatomical Resection of the Dorsal Segment of the Right Anterior Section Using an Extrahepatic Glissonean Approach: 3D Reconstruction Simulation and ICG Fluorescent Navigation.

Kim J, Park H Ann Surg Oncol. 2025; .

PMID: 39962003 DOI: 10.1245/s10434-025-17006-4.

Surgical treatment for hepatocellular carcinoma in era of multidisciplinary strategies.

Takamoto T, Mihara Y, Nishioka Y, Ichida A, Kawaguchi Y, Akamatsu N Int J Clin Oncol. 2025; 30(3):417-426.

PMID: 39907863 PMC: 11842484. DOI: 10.1007/s10147-025-02703-7.

ASO Author Reflections: Potential for Fluorescence-Guided Liver Surgery Utilizing Fluorescence Intensity Differences from Multiple Indocyanine Green Doses.

Kanda S, Nishino H, Nishio T, Awidah T, Chikamori K, Yoh T Ann Surg Oncol. 2025; 32(4):2485-2486.

PMID: 39900715 DOI: 10.1245/s10434-025-16953-2.

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