Regulation of Kidney Function and Metabolism: a Question of Supply and Demand

Overview

Journal Trans Am Clin Climatol Assoc

Specialty Rehabilitation Medicine

Date 2008 Jun 6

PMID 18528487

Citations 24

Authors

Roland C Blantz

Aihua Deng

Cynthia M Miracle

Scott C Thomson

Affiliations

Soon will be listed here.

Abstract

Kidney blood flow and glomerular filtration rate (GFR) are maintained relatively constant by hormonal influences and by efficient autoregulation. However, the kidney remains at risk for ischemia and acute kidney injury. Increases in kidney blood flow cause parallel increments in GFR, thereby dictating tubular reabsorption and increased oxygen/metabolic demands. Coordination between kidney blood flow and GFR with tubular reabsorption is maintained by the tubuloglomerular feedback (TGF) system whereby delivery of NaCl to the macula densa varies inversely with nephron GFR. Metabolic products, ATP and adenosine, are the mediators of TGF via afferent arteriolar vasoconstriction, and nitric oxide; COX-2 products and angiotensin II are modulators of acute TGF responses and temporal adaptation of TGF. Oxygen requirements and metabolic efficiency of Na transport in the kidney are significant variables that are regulated by both mediators and modulators of TGF. These metabolic and hormonal substances efficiently regulate both kidney supply and demand.

Citing Articles

Temporary bilateral clamping of renal arteries induces ischemia-reperfusion: A new pig model of acute kidney injury using total intravenous anesthesia.

Guilpin A, Magnin M, Aigle A, Ayoub J, Schuhler T, Lac R Physiol Rep. 2025; 13(3):e70203.

PMID: 39895016 PMC: 11788332. DOI: 10.14814/phy2.70203.

Impact of aging on vascular ion channels: perspectives and knowledge gaps across major organ systems.

Behringer E Am J Physiol Heart Circ Physiol. 2023; 325(5):H1012-H1038.

PMID: 37624095 PMC: 10908410. DOI: 10.1152/ajpheart.00288.2023.

Biomarkers of sickle cell nephropathy in Senegal.

Ndour E, Mnika K, Tall F, Seck M, Ly I, Nembaware V PLoS One. 2022; 17(11):e0273745.

PMID: 36409722 PMC: 9678278. DOI: 10.1371/journal.pone.0273745.

The Protective Role of Prolyl Oligopeptidase (POP) Inhibition in Kidney Injury Induced by Renal Ischemia-Reperfusion.

Casili G, Ardizzone A, Basilotta R, Lanza M, Filippone A, Paterniti I Int J Mol Sci. 2021; 22(21).

PMID: 34769337 PMC: 8584363. DOI: 10.3390/ijms222111886.

Non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (IVIM) MRI.

Feng Y, Chen X, Cheng Z, Lin Q, Chen P, Si-Tu D BMC Nephrol. 2021; 22(1):321.

PMID: 34565330 PMC: 8474753. DOI: 10.1186/s12882-021-02530-8.

References

De Nicola L, Blantz R, Gabbai F . Nitric oxide and angiotensin II. Glomerular and tubular interaction in the rat. J Clin Invest. 1992; 89(4):1248-56. PMC: 442985. DOI: 10.1172/JCI115709. View

Thomson S, Deng A, Bao D, Satriano J, Blantz R, Vallon V . Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes. J Clin Invest. 2001; 107(2):217-24. PMC: 199175. DOI: 10.1172/JCI10963. View

Korner A, Eklof A, Celsi G, Aperia A . Increased renal metabolism in diabetes. Mechanism and functional implications. Diabetes. 1994; 43(5):629-33. DOI: 10.2337/diab.43.5.629. View

Narsipur S, Peterson O, Smith R, Bigby T, Parthasarathy S, Gabbai F . Mechanisms of glomerular immune injury: effects of antioxidant treatment. J Am Soc Nephrol. 2003; 14(7):1748-55. DOI: 10.1097/01.asn.0000073903.29685.67. View

Schnermann J, Levine D . Paracrine factors in tubuloglomerular feedback: adenosine, ATP, and nitric oxide. Annu Rev Physiol. 2002; 65:501-29. DOI: 10.1146/annurev.physiol.65.050102.085738. View

Satriano J, Wead L, Cardus A, Deng A, Boss G, Thomson S . Regulation of ecto-5'-nucleotidase by NaCl and nitric oxide: potential roles in tubuloglomerular feedback and adaptation. Am J Physiol Renal Physiol. 2006; 291(5):F1078-82. DOI: 10.1152/ajprenal.00043.2006. View

Huang D, Vallon V, Zimmermann H, Koszalka P, Schrader J, Osswald H . Ecto-5'-nucleotidase (cd73)-dependent and -independent generation of adenosine participates in the mediation of tubuloglomerular feedback in vivo. Am J Physiol Renal Physiol. 2006; 291(2):F282-8. DOI: 10.1152/ajprenal.00113.2005. View

Brown G, Borutaite V . Nitric oxide, cytochrome c and mitochondria. Biochem Soc Symp. 2000; 66:17-25. DOI: 10.1042/bss0660017. View

Andersson U, Leighton B, Young M, Blomstrand E, Newsholme E . Inactivation of aconitase and oxoglutarate dehydrogenase in skeletal muscle in vitro by superoxide anions and/or nitric oxide. Biochem Biophys Res Commun. 1998; 249(2):512-6. DOI: 10.1006/bbrc.1998.9171. View

10.

Bell P, Lapointe J, Sabirov R, Hayashi S, Peti-Peterdi J, Manabe K . Macula densa cell signaling involves ATP release through a maxi anion channel. Proc Natl Acad Sci U S A. 2003; 100(7):4322-7. PMC: 153091. DOI: 10.1073/pnas.0736323100. View

11.

Schurek H, Jost U, Baumgartl H, Bertram H, HECKMANN U . Evidence for a preglomerular oxygen diffusion shunt in rat renal cortex. Am J Physiol. 1990; 259(6 Pt 2):F910-5. DOI: 10.1152/ajprenal.1990.259.6.F910. View

12.

Siragy H, Linden J . Sodium intake markedly alters renal interstitial fluid adenosine. Hypertension. 1996; 27(3 Pt 1):404-7. DOI: 10.1161/01.hyp.27.3.404. View

13.

Moncada S, Erusalimsky J . Does nitric oxide modulate mitochondrial energy generation and apoptosis?. Nat Rev Mol Cell Biol. 2002; 3(3):214-20. DOI: 10.1038/nrm762. View

14.

GUYTON A, LANGSTON J, NAVAR G . THEORY FOR RENAL AUTOREGULATION BY FEEDBACK AT THE JUXTAGLOMERULAR APPARATUS. Circ Res. 1964; 15:SUPPL:187-97. View

15.

Castrop H, Huang Y, Hashimoto S, Mizel D, Hansen P, Theilig F . Impairment of tubuloglomerular feedback regulation of GFR in ecto-5'-nucleotidase/CD73-deficient mice. J Clin Invest. 2004; 114(5):634-42. PMC: 514589. DOI: 10.1172/JCI21851. View

16.

Brown R, Ollerstam A, Persson A . Neuronal nitric oxide synthase inhibition sensitizes the tubuloglomerular feedback mechanism after volume expansion. Kidney Int. 2004; 65(4):1349-56. DOI: 10.1111/j.1523-1755.2004.00509.x. View

17.

Thomson S, Vallon V, Blantz R . Reduced proximal reabsorption resets tubuloglomerular feedback in euvolemic rats. Am J Physiol. 1997; 273(4):R1414-20. DOI: 10.1152/ajpregu.1997.273.4.R1414. View

18.

Brenner B, Troy J, Daugharty T, Deen W, ROBERTSON C . Dynamics of glomerular ultrafiltration in the rat. II. Plasma-flow dependence of GFR. Am J Physiol. 1972; 223(5):1184-90. DOI: 10.1152/ajplegacy.1972.223.5.1184. View

19.

Deng A, Miracle C, Suarez J, Lortie M, Satriano J, Thomson S . Oxygen consumption in the kidney: effects of nitric oxide synthase isoforms and angiotensin II. Kidney Int. 2005; 68(2):723-30. DOI: 10.1111/j.1523-1755.2005.00450.x. View

20.

Thomson S, Bachmann S, Bostanjoglo M, Ecelbarger C, Peterson O, Schwartz D . Temporal adjustment of the juxtaglomerular apparatus during sustained inhibition of proximal reabsorption. J Clin Invest. 1999; 104(8):1149-58. PMC: 408569. DOI: 10.1172/JCI5156. View