Celecoxib As an in Vivo Probe of Cyclooxygenase-2 Mechanisms Underlying Retrograde Amnesia in an Animal Model of ECT

Overview

Journal J Neural Transm (Vienna)

Specialties Neurology
Physiology

Date 2008 Jun 5

PMID 18523723

Citations 5

Authors

Chittaranjan Andrade

Shivashanmugam Thyagarajan

Nagendra Madan Singh

Pabbisetty S Vinod

N Sanjay Kumar Rao

J Suresh Chandra

Affiliations

Soon will be listed here.

Abstract

Background: Cyclooxygenase-2 (COX-2) mechanisms are involved in glutamate-mediated learning and memory as well as in glutamatergic excitotoxicity. Electroconvulsive therapy (ECT)-induced amnesia may arise from glutamatergic excitotoxicity; if so, COX-2 inhibition may attenuate retrograde amnesia with ECT.

Methods: Wistar rats which received celecoxib (15 mg/kg per day) or vehicle for 18 days were trained for 3 days on a passive avoidance task. On each of the next 3 days, rats which showed perfect learning (n=51) received true or sham suprathreshold electroconvulsive shocks (ECS; 60 mC) in a factorial design; daily dosing with drug or vehicle was continued. One day after the last ECS, recall of pre-ECS learning was tested.

Results: ECS-treated rats showed impaired recall in the vehicle but not celecoxib group. Celecoxib significantly protected against ECS-induced retrograde amnesia; this benefit was independent of the drug-induced attenuation of ECS seizure duration.

Conclusions: Celecoxib may protect against ECS-induced retrograde amnesia by attenuating ECS-induced, COX-2-mediated glutamatergic excitotoxicity.

Citing Articles

Searching for the mechanism(s) of ECT's therapeutic effect.

McCall W, Andrade C, Sienaert P J ECT. 2014; 30(2):87-9.

PMID: 24755719 PMC: 4695970. DOI: 10.1097/YCT.0000000000000121.

Orchestrated regulation of Nogo receptors, LOTUS, AMPA receptors and BDNF in an ECT model suggests opening and closure of a window of synaptic plasticity.

Nordgren M, Karlsson T, Svensson M, Koczy J, Josephson A, Olson L PLoS One. 2013; 8(11):e78778.

PMID: 24244357 PMC: 3828303. DOI: 10.1371/journal.pone.0078778.

Administration of a selective glucocorticoid antagonist attenuates electroconvulsive shock-induced retrograde amnesia.

Andrade C, Shaikh S, Narayan L, Blasey C, Belanoff J J Neural Transm (Vienna). 2011; 119(3):337-44.

PMID: 21922193 DOI: 10.1007/s00702-011-0712-8.

Molecular mechanisms underlying electroconvulsive therapy-induced amnestic deficits: A decade of research.

Andrade C Indian J Psychiatry. 2009; 50(4):244-52.

PMID: 19823608 PMC: 2755145. DOI: 10.4103/0019-5545.44745.

Continuing medical education.

Andrade C Indian J Psychiatry. 2009; 50(3):209-12.

PMID: 19742183 PMC: 2738364. DOI: 10.4103/0019-5545.43631.

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