Loss of Heterozygosity at Chromosome 14q is Associated with Poor Prognosis in Head and Neck Squamous Cell Carcinomas

Overview

Journal J Cancer Res Clin Oncol

Specialty Oncology

Date 2008 Jun 4

PMID 18521630

Citations 11

Authors

Davut Pehlivan

Esra Gunduz

Mehmet Gunduz

Hitoshi Nagatsuka

Levent Bekir Beder

Beyhan Cengiz

Rosario S Rivera

Kunihiro Fukushima

Sukru Palanduz

Sukru Ozturk

Noboru Yamanaka

Kenji Shimizu

Affiliations

Soon will be listed here.

Abstract

Purpose And Methods: Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs.

Results: Three regions were detected to have a high LOH rate which included 14q21.2-22.3 (42.5%), 14q31 (55%), and 14q32.1 (37%). The correlation between LOH and clinicopathological findings was investigated through statistical analyses. A strong correlation was observed between the highest LOH marker and the overall and disease-free survival.

Conclusions: The results suggest that the distal part of chromosome 14 may host a TSG that may lead to the development and/or progression of HNSCCs. Several genes such as CHES1, BMP4, SAV, and PNN have arisen as candidate tumor suppressors in the region.

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