Leiomyosarcoma of the Great Saphenous Vein: a Case Report and Review of the Literature

Overview

Journal Sarcoma

Publisher Wiley

Date 2008 Jun 4

PMID 18521408

Citations 7

Authors

Alexander G J Marle

Maarten W G A Bronkhorst

Mark A M Brouwers

Affiliations

Soon will be listed here.

Abstract

Introduction: Leiomyosarcoma of the venous system is rare, even more so in the greater saphenous vein. In the 85 years since van Ree described the first case in 1919 only 25 cases have been reported in the world.

Methods: We describe a case of an 85-year-old woman who was successfully treated by excision of the tumour. We also reviewed pertinent literature with regard to age, gender spread, tumour size, survival, occurrence of metastases and therapy.

Results: The median age was 54 years (range 2-85 years), with a 3:2 female to male ratio. The median size of the tumours was 4.1 cm (range 2-12 cm) and metastases occurred in seven of the 25 cases. If any form of adjuvant therapy is used it is usually radiotherapy. Chemotherapy seems to be reserved for cases where metastasis occurs. Average survival was 4 years (range 1 month to 17 years). Currently the best treatment seems to be wide excision of the tumour, with selective vascular reconstruction combined with adjuvant radiotherapy.

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References

Song K, Jang Y, Kim M, Lee G, Sung R . Leiomyosarcoma arising in the great saphenous vein--a case report. J Korean Med Sci. 1991; 6(4):372-5. PMC: 3049718. DOI: 10.3346/jkms.1991.6.4.372. View

Humphrey M, Neff J, Lin F, Krishnan L . Leiomyosarcoma of the saphenous vein. A case report and review of the literature. J Bone Joint Surg Am. 1987; 69(2):282-6. View

Byard R, Bourne A, Phillips G, Rice M, Davey R . Leiomyosarcoma of the saphenous vein in a child with 12-year follow-up. J Pediatr Surg. 1993; 28(2):271-4. DOI: 10.1016/s0022-3468(05)80294-5. View

Stallard D, Sundaram M, Johnson F, Janney C . Case report 747: Leiomyosarcoma of great saphenous vein. Skeletal Radiol. 1992; 21(6):399-401. DOI: 10.1007/BF00241821. View

Stringer B . Leiomyosarcoma of artery and vein. Am J Surg. 1977; 134(1):90-4. DOI: 10.1016/0002-9610(77)90289-6. View

Smout M, Fisher J . Leiomyosarcoma of the Saphenous Vein. Can Med Assoc J. 2010; 83(20):1066-7. PMC: 1938813. View

FISCHER M, GELB A, Nussbaum M, Haveson S, Ghali V . Primary smooth muscle tumors of venous origin. Ann Surg. 1982; 196(6):720-4. PMC: 1352992. DOI: 10.1097/00000658-198212001-00019. View

Christiansen J . [MALIGNANT TUMORS ORIGINATING FROM THE VENOUS SYSTEM. REVIEW AND A CASE OF LEIOMYOSARCOMA FROM THE LONG SAPHENOUS VEIN]. Ugeskr Laeger. 1964; 126:483-5. View

Saglik Y, Icli F, Uluoglu O, Isiklar Z . Leiomyosarcoma of the great saphenous vein. Int Orthop. 1992; 16(2):185-7. DOI: 10.1007/BF00180214. View

10.

Hughes S . A case of leiomyosarcoma of the long saphenous vein. Vasc Surg. 1973; 7(2):71-3. DOI: 10.1177/153857447300700202. View

11.

Szasz I, Barr R, SCOBIE T . Leiomyosarcoma arising from veins:two cases and a review of the literature on venous neoplasms. Can J Surg. 1969; 12(4):415-9. View

12.

JERNSTROM P, GOWDY R . Leiomyosarcoma of the long saphenous vein. Am J Clin Pathol. 1975; 63(1):25-31. DOI: 10.1093/ajcp/63.3.25. View

13.

Welk E, Bindewald H, Berndt R . [Vascular leiomyosarcoma--a surgical rarity]. Chirurg. 1991; 62(3):223-5. View

14.

Leu H, Nipkow P . Malignant primary vein tumors. Angiologica. 1969; 6(5):302-9. DOI: 10.1159/000157799. View

15.

Berlin O, STENER B, Kindblom L, Angervall L . Leiomyosarcomas of venous origin in the extremities. A correlated clinical, roentgenologic, and morphologic study with diagnostic and surgical implications. Cancer. 1984; 54(10):2147-59. DOI: 10.1002/1097-0142(19841115)54:10<2147::aid-cncr2820541015>3.0.co;2-9. View

16.

Stambuk J, Oddo D, Perez R, Bravo M . [Leiomyosarcoma of the saphenous vein]. Rev Med Chil. 1993; 121(6):673-6. View

17.

Gross E, Horton M . Leiomyosarcoma of the saphenous vein. J Pathol. 1975; 116(1):37-41. DOI: 10.1002/path.1711160106. View

18.

Reix T, Sevestre H, Szychta P, Pietri J . Primary malignant tumors of the venous system in the lower extremities. Ann Vasc Surg. 1998; 12(6):589-96. DOI: 10.1007/s100169900205. View

19.

Mutter D, Limacher J, Beaujeux R, Meyer A, Roy C, Bergerat J . [Primary leiomyosarcoma of the femoral vein. Therapeutic aspects]. J Chir (Paris). 1994; 131(11):457-60. View

20.

Dzsinich C, Gloviczki P, Van Heerden J, Nagorney D, Pairolero P, Johnson C . Primary venous leiomyosarcoma: a rare but lethal disease. J Vasc Surg. 1992; 15(4):595-603. View