Skeletal Muscle Dressed in SOCs

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 2008 Jun 4

PMID 18521070

Citations 11

Authors

Dong Min Shin

Shmuel Muallem

Affiliations

Soon will be listed here.

Abstract

Store-operated Ca(2+) channels (SOCs) are activated in response to Ca(2+) release from the endoplasmic reticulum (ER). The stromal interaction molecule 1 (STIM1) is the ER sensor that transmits the stored Ca(2+) content to the pore-forming SOCs Orai and TRPC channels. Recent studies reveal high levels of Orai1 and STIM1 in skeletal muscle, and a prominent role of SOCs in muscle development and function.

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