Toll-like Receptor Signaling in the Ischemic Heart

Overview

Journal Front Biosci

Specialty Biology

Date 2008 May 30

PMID 18508620

Citations 18

Authors

Stefan Frantz

Georg Ertl

Johann Bauersachs

Affiliations

Soon will be listed here.

Abstract

Toll-like receptors (TLRs) have been identified as primary innate immune receptors. They distinguish among different patterns of pathogens and rapidly activate an innate immune response. However, TLRs can also be stimulated by host-derived molecules. TLRs are expressed in the cardiovascular system and could thus be a key link between cardiovascular diseases and the immune system. Increasing evidence suggests that TLR signaling promotes injury in the heart after ischemia, ischemia/reperfusion or hypertrophic stimuli. Herein we review the experimental and clinical evidence for the involvement of TLR and its downstream signaling molecules in cardiac ischemic injury.

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