Converging Roles for Sphingolipids and Cell Stress in the Progression of Neuro-AIDS

Overview

Journal Front Biosci

Specialty Biology

Date 2008 May 30

PMID 18508574

Citations 15

Authors

Norman J Haughey

Joesph Steiner

Avindra Nath

Justin C McArthur

Ned Sacktor

Carlos Pardo

Veera Venkata Ratnam Bandaru

Affiliations

Soon will be listed here.

Abstract

Sphingolipids are a class of lipids enriched in the central nervous system that have important roles in signal transduction. Recent advances in our understanding of how sphingolipids are involved in the control of life and death signaling have uncovered roles for these lipids in the neuropathogenesis of HIV-associated neurocognitive disorders (HAND). In this review we briefly summarize the molecular mechanisms involved in the pathological production of the toxic sphingolipid, ceramide and address questions of how cytokine and cellular stress pathways that are perturbed in HAND converge to deregulate ceramide-associated signaling.

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