The Role of Chemokines During Herpes Simplex Virus-1 Infection

Overview

Journal Front Biosci

Specialty Biology

Date 2008 May 30

PMID 18508551

Citations 34

Authors

Todd R Wuest

Daniel J J Carr

Affiliations

Soon will be listed here.

Abstract

Herpes simplex virus-type 1 is among the most prevalent and successful humans pathogens. Although infection is largely uncomplicated in the immunocompetent human host, HSV-1 infection can cause blinding corneal disease, and individuals with defects in innate or adaptive immunity are susceptible to herpes simplex encephalitis. Chemokines regulate leukocyte trafficking to inflamed tissues and play a crucial role in orchestrating the immune response to HSV-1 infection. In this review we will focus on the pathways that induce chemokine expression during HSV-1 infection and the implications of chemokine signaling on control of viral replication.

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References

Carpentier P, Williams B, Miller S . Distinct roles of protein kinase R and toll-like receptor 3 in the activation of astrocytes by viral stimuli. Glia. 2006; 55(3):239-52. DOI: 10.1002/glia.20450. View

Looker K, Garnett G . A systematic review of the epidemiology and interaction of herpes simplex virus types 1 and 2. Sex Transm Infect. 2005; 81(2):103-7. PMC: 1764655. DOI: 10.1136/sti.2004.012039. View

Luster A . The role of chemokines in linking innate and adaptive immunity. Curr Opin Immunol. 2002; 14(1):129-35. DOI: 10.1016/s0952-7915(01)00308-9. View

Cose S, Kelly J, Carbone F . Characterization of diverse primary herpes simplex virus type 1 gB-specific cytotoxic T-cell response showing a preferential V beta bias. J Virol. 1995; 69(9):5849-52. PMC: 189458. DOI: 10.1128/JVI.69.9.5849-5852.1995. View

Verjans G, Hintzen R, van Dun J, Poot A, Milikan J, Laman J . Selective retention of herpes simplex virus-specific T cells in latently infected human trigeminal ganglia. Proc Natl Acad Sci U S A. 2007; 104(9):3496-501. PMC: 1805572. DOI: 10.1073/pnas.0610847104. View

Khanna K, Bonneau R, Kinchington P, Hendricks R . Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia. Immunity. 2003; 18(5):593-603. PMC: 2871305. DOI: 10.1016/s1074-7613(03)00112-2. View

Alt C, Laschinger M, Engelhardt B . Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune.... Eur J Immunol. 2002; 32(8):2133-44. DOI: 10.1002/1521-4141(200208)32:8<2133::AID-IMMU2133>3.0.CO;2-W. View

Kumar A, Humphreys T, Kremer K, Bramati P, Bradfield L, Edgar C . CXCR4 physically associates with the T cell receptor to signal in T cells. Immunity. 2006; 25(2):213-24. DOI: 10.1016/j.immuni.2006.06.015. View

Robertson M . Role of chemokines in the biology of natural killer cells. J Leukoc Biol. 2002; 71(2):173-83. View

10.

Dar W, Knechtle S . CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor. Immunology. 2007; 120(4):467-85. PMC: 2265907. DOI: 10.1111/j.1365-2567.2006.02534.x. View

11.

Carr D, Campbell I . Herpes simplex virus type 1 induction of chemokine production is unrelated to viral load in the cornea but not in the nervous system. Viral Immunol. 2007; 19(4):741-6. PMC: 1766944. DOI: 10.1089/vim.2006.19.741. View

12.

Khan I, Thomas S, Moretto M, Lee F, Islam S, Combe C . CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection. PLoS Pathog. 2006; 2(6):e49. PMC: 1475660. DOI: 10.1371/journal.ppat.0020049. View

13.

Viola A, Contento R, Molon B . T cells and their partners: The chemokine dating agency. Trends Immunol. 2006; 27(9):421-7. DOI: 10.1016/j.it.2006.07.004. View

14.

Murdoch C, Finn A . Chemokine receptors and their role in inflammation and infectious diseases. Blood. 2000; 95(10):3032-43. View

15.

Vianello F, Olszak I, Poznansky M . Fugetaxis: active movement of leukocytes away from a chemokinetic agent. J Mol Med (Berl). 2005; 83(10):752-63. DOI: 10.1007/s00109-005-0675-z. View

16.

Hess C, Means T, Autissier P, Woodberry T, Altfeld M, Addo M . IL-8 responsiveness defines a subset of CD8 T cells poised to kill. Blood. 2004; 104(12):3463-71. DOI: 10.1182/blood-2004-03-1067. View

17.

Suzuki N, Saito T . IRAK-4--a shared NF-kappaB activator in innate and acquired immunity. Trends Immunol. 2006; 27(12):566-72. DOI: 10.1016/j.it.2006.10.003. View

18.

French A, Yokoyama W . Natural killer cells and viral infections. Curr Opin Immunol. 2002; 15(1):45-51. DOI: 10.1016/s095279150200002x. View

19.

Lafon M, Megret F, Lafage M, Prehaud C . The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA. J Mol Neurosci. 2006; 29(3):185-94. DOI: 10.1385/JMN:29:3:185. View

20.

Bonnet M, Weil R, Dam E, Hovanessian A, Meurs E . PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex. Mol Cell Biol. 2000; 20(13):4532-42. PMC: 85837. DOI: 10.1128/MCB.20.13.4532-4542.2000. View