Value of Anti-mutated Citrullinated Vimentin Antibodies in Diagnosing Rheumatoid Arthritis

Overview

Journal Rheumatol Int

Specialty Rheumatology

Date 2008 May 23

PMID 18496693

Citations 18

Authors

Rim Sghiri

Elyes Bouajina

Dhaker Bargaoui

Latifa Harzallah

Hosni Ben Fredj

Samar Sammoud

Ibtissem Ghedira

Affiliations

Soon will be listed here.

Abstract

We assessed the diagnostic value of anti-mutated citrullinated vimentin antibodies (anti-MCV) and compared it with those of anti-cyclic citrullinated peptide antibodies (anti-CCP), IgA (ARF), IgM (MRF) and IgG (GRF) rheumatoid factors for rheumatoid arthritis (RA). Serum samples of 170 RA patients, with early and established RA, and 309 controls were tested for anti-MCV, anti-CCP, ARF, MRF and GRF using commercially available ELISA kits. Cut off of different tests was determined with ROC curves. The sensitivity and the specificity of anti-MCV were 74.1 and 79%, respectively. Sixty-five of 309 (21%) controls were anti-MCV positive. Sensitivity and specificity of anti-CCP were 72.4 and 96.1%, respectively. Only 12 of 309 (3.9%) controls were anti-CCP positive. Sensitivity of ARF, MRF and GRF were 64.1, 65.9 and 68.2%, respectively. Their specificity was 79.6, 74.4 and 68.9%, respectively. No significant association was observed between the antibodies tested and extrarticular manifestations. Anti-MCV shows comparable sensitivity but lower specificity than that of anti-CCP. They do not appear to be very useful in the diagnosis of RA.

Citing Articles

Autoantibodies Serum Level and 10-Year Risk of Fractures Evaluated by FRAX Tool in Rheumatoid Arthritis Patients.

Sghiri R, Ben Hassine H, Ghozzi M, El Amri N, Baccouche K, Sarraj R Open Access Rheumatol. 2024; 16:137-145.

PMID: 39045423 PMC: 11265213. DOI: 10.2147/OARRR.S466625.

Anticardiolipin and anti-beta 2-glycoprotein I antibodies in patients with unexplained articular manifestations.

Melayah S, Ghozzi M, Ghedira I, Mankai A J Clin Lab Anal. 2022; 37(1):e24812.

PMID: 36514859 PMC: 9833978. DOI: 10.1002/jcla.24812.

Frequency of serological markers of rheumatoid arthritis in patients with IgA anti-β2 glycoprotein I antibodies.

Melayah S, Ghozzi M, Mankai A, Mechi F, Ghedira I J Clin Lab Anal. 2022; 36(7):e24537.

PMID: 35666694 PMC: 9279944. DOI: 10.1002/jcla.24537.

Frequency of serological markers of rheumatoid arthritis in adult patients with active celiac disease.

Ghozzi M, Melayah S, Adaily N, Ghedira I J Clin Lab Anal. 2022; 36(3):e24249.

PMID: 35060192 PMC: 8906036. DOI: 10.1002/jcla.24249.

IgA is the predominant isotype of anti-β2 glycoprotein I antibodies in rheumatoid arthritis.

Melayah S, Changuel M, Mankai A, Ghedira I J Clin Lab Anal. 2020; 34(6):e23217.

PMID: 31967351 PMC: 7307372. DOI: 10.1002/jcla.23217.

References

Despres N, Boire G, Lopez-Longo F, Menard H . The Sa system: a novel antigen-antibody system specific for rheumatoid arthritis. J Rheumatol. 1994; 21(6):1027-33. View

Chapuy-Regaud S, Sebbag M, Baeten D, Clavel C, Foulquier C, De Keyser F . Fibrin deimination in synovial tissue is not specific for rheumatoid arthritis but commonly occurs during synovitides. J Immunol. 2005; 174(8):5057-64. DOI: 10.4049/jimmunol.174.8.5057. View

Goldbach-Mansky R, Lee J, McCoy A, Hoxworth J, Yarboro C, Smolen J . Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset. Arthritis Res. 2000; 2(3):236-43. PMC: 17811. DOI: 10.1186/ar93. View

Nielen M, van Schaardenburg D, Reesink H, van de Stadt R, van der Horst-Bruinsma I, de Koning M . Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum. 2004; 50(2):380-6. DOI: 10.1002/art.20018. View

Dejaco C, Klotz W, Larcher H, Duftner C, Schirmer M, Herold M . Diagnostic value of antibodies against a modified citrullinated vimentin in rheumatoid arthritis. Arthritis Res Ther. 2006; 8(4):R119. PMC: 1779400. DOI: 10.1186/ar2008. View

Vannini A, Cheung K, Fusconi M, Stammen-Vogelzangs J, Drenth J, DallAglio A . Anti-cyclic citrullinated peptide positivity in non-rheumatoid arthritis disease samples: citrulline-dependent or not?. Ann Rheum Dis. 2006; 66(4):511-6. PMC: 1856034. DOI: 10.1136/ard.2006.058933. View

Hayem G, Chazerain P, Combe B, Elias A, Haim T, Nicaise P . Anti-Sa antibody is an accurate diagnostic and prognostic marker in adult rheumatoid arthritis. J Rheumatol. 1999; 26(1):7-13. View

Ota F, Maeshima A, Yamashita S, Ikeuchi H, Kaneko Y, Kuroiwa T . Activin A induces cell proliferation of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Rheum. 2003; 48(9):2442-9. DOI: 10.1002/art.11249. View

Bas S, Perneger T, Mikhnevitch E, Seitz M, Tiercy J, Roux-Lombard P . Association of rheumatoid factors and anti-filaggrin antibodies with severity of erosions in rheumatoid arthritis. Rheumatology (Oxford). 2000; 39(10):1082-8. DOI: 10.1093/rheumatology/39.10.1082. View

10.

De Rycke L, Peene I, Hoffman I, Kruithof E, Union A, Meheus L . Rheumatoid factor and anticitrullinated protein antibodies in rheumatoid arthritis: diagnostic value, associations with radiological progression rate, and extra-articular manifestations. Ann Rheum Dis. 2004; 63(12):1587-93. PMC: 1754859. DOI: 10.1136/ard.2003.017574. View

11.

Sghiri R, Bouagina E, Zaglaoui H, Mestiri H, Harzallah L, Harrabi I . Diagnostic performances of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis. Rheumatol Int. 2007; 27(12):1125-30. DOI: 10.1007/s00296-007-0351-4. View

12.

Bizzaro N . Antibodies to citrullinated peptides: a significant step forward in the early diagnosis of rheumatoid arthritis. Clin Chem Lab Med. 2007; 45(2):150-7. DOI: 10.1515/CCLM.2007.027. View

13.

Xue C, Takahashi M, Hasunuma T, Aono H, Yamamoto K, Yoshino S . Characterisation of fibroblast-like cells in pannus lesions of patients with rheumatoid arthritis sharing properties of fibroblasts and chondrocytes. Ann Rheum Dis. 1997; 56(4):262-7. PMC: 1752353. DOI: 10.1136/ard.56.4.262. View

14.

Vossenaar E, Despres N, Lapointe E, van der Heijden A, Lora M, Senshu T . Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin. Arthritis Res Ther. 2004; 6(2):R142-50. PMC: 400433. DOI: 10.1186/ar1149. View

15.

Coenen D, Verschueren P, Westhovens R, Bossuyt X . Technical and diagnostic performance of 6 assays for the measurement of citrullinated protein/peptide antibodies in the diagnosis of rheumatoid arthritis. Clin Chem. 2007; 53(3):498-504. DOI: 10.1373/clinchem.2006.078063. View

16.

Bongartz T, Cantaert T, Atkins S, Harle P, Myers J, Turesson C . Citrullination in extra-articular manifestations of rheumatoid arthritis. Rheumatology (Oxford). 2006; 46(1):70-5. DOI: 10.1093/rheumatology/kel202. View