Protein Quality Control and Degradation in Cardiomyocytes

Overview

Journal J Mol Cell Cardiol

Specialty Cardiology & Vascular Diseases

Date 2008 May 23

PMID 18495153

Citations 66

Authors

Xuejun Wang

Huabo Su

Mark J Ranek

Affiliations

Soon will be listed here.

Abstract

The heart is constantly under stress and cardiomyocytes face enormous challenges to correctly fold nascent polypeptides and keep mature proteins from denaturing. To meet the challenge, cardiomyocytes have developed multi-layered protein quality control (PQC) mechanisms which are carried out primarily by chaperones and ubiquitin-proteasome system mediated proteolysis. Autophagy may also participate in PQC in cardiomyocytes, especially under pathological conditions. Cardiac PQC often becomes inadequate in heart disease, which may play an important role in the development of congestive heart failure.

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