Discrepancies Between the Responses to Skin Prick Test to Food and Respiratory Antigens in Two Subtypes of Patients with Irritable Bowel Syndrome

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2008 May 22

PMID 18494056

Citations 2

Authors

Rosa-Ls Soares

Hamilton-N Figueiredo

Jose-M Santos

Rita-F Oliveira

Raquel-L Godoy

Felipe-Ap Mendonca

Affiliations

Soon will be listed here.

Abstract

Aim: To compare the response to skin prick tests (SPTs) to food antigens (FAs) and inhalant allergens (IAs) in patients with two subtypes of irritable bowel syndrome (IBS) and healthy controls.

Methods: We compared the results of SPTs for IAs and FAs in 87 volunteers divided into three groups: diarrhea predominant IBS (D-IBS) Group I (n = 19), constipation predominant IBS (C-IBS) Group II (n = 17), and normal controls Group III (n = 51).

Results: Of the 285 tests (171 for FAs and 114 for IAs) performed in Group I we obtained 45 (26.3%) positive responses for FA and 23 (20.1%) for IA. Of the 153 tests for FA in Group II, we obtained 66 (20.1%) positive responses, and of the 102 tests for IA, we obtained 20 (19.6%) positive responses. Of the 459 tests for FA performed in Group III, we obtained 39 (84%) positive responses, and of the 306 for IA, we obtained 52 (16.9%) positive responses. The numbers of positive responses were not significantly different between the three groups, but in the D-IBS group, the number of SPT FA responses differed significantly from those for the other two groups (P > 0.01).

Conclusion: Despite the small number of cases studied, the higher reactivity to FAs in Group I compared to Groups II and III adds new information, and suggests the presence of a possible alteration in intestinal epithelial function.

Citing Articles

Fructo-oligosaccharide intensifies visceral hypersensitivity and intestinal inflammation in a stress-induced irritable bowel syndrome mouse model.

Chen B, Du L, He H, Kim J, Zhao Y, Zhang Y World J Gastroenterol. 2018; 23(47):8321-8333.

PMID: 29307992 PMC: 5743503. DOI: 10.3748/wjg.v23.i47.8321.

Irritable bowel syndrome: a clinical review.

Soares R World J Gastroenterol. 2014; 20(34):12144-60.

PMID: 25232249 PMC: 4161800. DOI: 10.3748/wjg.v20.i34.12144.

References

Yazar A, Atis S, Konca K, Pata C, Akbay E, Calikoglu M . Respiratory symptoms and pulmonary functional changes in patients with irritable bowel syndrome. Am J Gastroenterol. 2001; 96(5):1511-6. DOI: 10.1111/j.1572-0241.2001.03748.x. View

Locke 3rd G, Zinsmeister A, Talley N, Fett S, Melton L . Risk factors for irritable bowel syndrome: role of analgesics and food sensitivities. Am J Gastroenterol. 2000; 95(1):157-65. DOI: 10.1111/j.1572-0241.2000.01678.x. View

Rhodes D, Wallace M . Post-infectious irritable bowel syndrome. Curr Gastroenterol Rep. 2006; 8(4):327-32. DOI: 10.1007/s11894-006-0054-0. View

Talley N, Zinsmeister A, Melton 3rd L . Irritable bowel syndrome in a community: symptom subgroups, risk factors, and health care utilization. Am J Epidemiol. 1995; 142(1):76-83. DOI: 10.1093/oxfordjournals.aje.a117548. View

Barbara G . Mucosal barrier defects in irritable bowel syndrome. Who left the door open?. Am J Gastroenterol. 2006; 101(6):1295-8. DOI: 10.1111/j.1572-0241.2006.00667.x. View

Unno N, Fink M . Intestinal epithelial hyperpermeability. Mechanisms and relevance to disease. Gastroenterol Clin North Am. 1998; 27(2):289-307. DOI: 10.1016/s0889-8553(05)70004-2. View

Simonato B, De Lazzari F, Pasini G, Polato F, Giannattasio M, Gemignani C . IgE binding to soluble and insoluble wheat flour proteins in atopic and non-atopic patients suffering from gastrointestinal symptoms after wheat ingestion. Clin Exp Allergy. 2001; 31(11):1771-8. DOI: 10.1046/j.1365-2222.2001.01200.x. View

Read N . Food and hypersensitivity in functional dyspepsia. Gut. 2002; 51 Suppl 1:i50-3. PMC: 1867731. DOI: 10.1136/gut.51.suppl_1.i50. View

Crowe S, Perdue M . Gastrointestinal food hypersensitivity: basic mechanisms of pathophysiology. Gastroenterology. 1992; 103(3):1075-95. DOI: 10.1016/0016-5085(92)90047-3. View

10.

Brandtzaeg P . Current understanding of gastrointestinal immunoregulation and its relation to food allergy. Ann N Y Acad Sci. 2002; 964:13-45. DOI: 10.1111/j.1749-6632.2002.tb04131.x. View

11.

Ahmed T, FUCHS G . Gastrointestinal allergy to food: a review. J Diarrhoeal Dis Res. 1998; 15(4):211-23. View

12.

Zar S, Benson M, Kumar D . Food-specific serum IgG4 and IgE titers to common food antigens in irritable bowel syndrome. Am J Gastroenterol. 2005; 100(7):1550-7. DOI: 10.1111/j.1572-0241.2005.41348.x. View

13.

Ozol D, Uz E, Bozalan R, Turkay C, Yildirim Z . Relationship between asthma and irritable bowel syndrome: role of food allergy. J Asthma. 2006; 43(10):773-5. DOI: 10.1080/02770900601031789. View

14.

Barbara G, De Giorgio R, Stanghellini V, Cremon C, Corinaldesi R . A role for inflammation in irritable bowel syndrome?. Gut. 2002; 51 Suppl 1:i41-4. PMC: 1867730. DOI: 10.1136/gut.51.suppl_1.i41. View

15.

Uz E, Turkay C, Aytac S, Bavbek N . Risk factors for irritable bowel syndrome in Turkish population: role of food allergy. J Clin Gastroenterol. 2007; 41(4):380-3. DOI: 10.1097/01.mcg.0000225589.70706.24. View

16.

Roussos A, Koursarakos P, Patsopoulos D, Gerogianni I, Philippou N . Increased prevalence of irritable bowel syndrome in patients with bronchial asthma. Respir Med. 2003; 97(1):75-9. DOI: 10.1053/rmed.2001.1409. View

17.

Mayer E, Collins S . Evolving pathophysiologic models of functional gastrointestinal disorders. Gastroenterology. 2002; 122(7):2032-48. DOI: 10.1053/gast.2002.33584. View

18.

PETITPIERRE M, Gumowski P, Girard J . Irritable bowel syndrome and hypersensitivity to food. Ann Allergy. 1985; 54(6):538-40. View

19.

Niec A, Frankum B, Talley N . Are adverse food reactions linked to irritable bowel syndrome?. Am J Gastroenterol. 1998; 93(11):2184-90. DOI: 10.1111/j.1572-0241.1998.00531.x. View

20.

Atkinson W, Sheldon T, Shaath N, Whorwell P . Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial. Gut. 2004; 53(10):1459-64. PMC: 1774223. DOI: 10.1136/gut.2003.037697. View