Origin, Regulation and Physiological Function of Intestinal Oeosinophils

Overview

Journal Best Pract Res Clin Gastroenterol

Publisher Elsevier

Specialty Gastroenterology

Date 2008 May 22

PMID 18492563

Citations 10

Authors

Patricia C Fulkerson

Marc E Rothenberg

Affiliations

Soon will be listed here.

Abstract

Oeosinophils are pleiotropic multi-functional leukocytes that are typically associated with the initiation and propagation of inflammatory responses, particularly helminth infection and allergic disease. However, expanding evidence supports a broader role for oeosinophils in homoeostatic function and organ development and modulation of local immune responses via interaction with other effector cells. In this review, the biology of oeosinophils in the healthy gut is summarised. In particular, the molecular steps involved in oeosinophil development and trafficking are described, with special attention to the important role of the transcription factor GATA-1, the oeosinophil-selective cytokine IL-5 and the eotaxin subfamily of chemokines. In addition, the regulation of oeosinophil survival by inhibitory and death receptors and the expanding role for oeosinophils in health and disease are reviewed.

Citing Articles

Origins and functions of eosinophils in two non-mucosal tissues.

Day K, Rempel L, Rossi F, Theret M Front Immunol. 2024; 15:1368142.

PMID: 38585275 PMC: 10995313. DOI: 10.3389/fimmu.2024.1368142.

Systemic profile of immune factors in an elderly Italian population affected by chronic strongyloidiasis.

Tiberti N, Buonfrate D, Carbone C, Piro G, Bisoffi Z, Piubelli C Parasit Vectors. 2020; 13(1):515.

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Eosinophils in the gastrointestinal tract and their role in the pathogenesis of major colorectal disorders.

Loktionov A World J Gastroenterol. 2019; 25(27):3503-3526.

PMID: 31367153 PMC: 6658389. DOI: 10.3748/wjg.v25.i27.3503.

Temporal clinical, proteomic, histological and cellular immune responses of dextran sulfate sodium-induced acute colitis.

Nunes N, Kim S, Sundby M, Chandran P, Burks S, Paz A World J Gastroenterol. 2018; 24(38):4341-4355.

PMID: 30344419 PMC: 6189848. DOI: 10.3748/wjg.v24.i38.4341.

Eosinophils, probiotics, and the microbiome.

Rosenberg H, Masterson J, Furuta G J Leukoc Biol. 2016; 100(5):881-888.

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