Micelles and Nanoparticles for Ultrasonic Drug and Gene Delivery

Overview

Journal Adv Drug Deliv Rev

Specialty Pharmacology

Date 2008 May 20

PMID 18486269

Citations 91

Authors

Ghaleb A Husseini

William G Pitt

Affiliations

Soon will be listed here.

Abstract

Drug delivery research employing micelles and nanoparticles has expanded in recent years. Of particular interest is the use of these nanovehicles that deliver high concentrations of cytotoxic drugs to diseased tissues selectively, thus reducing the agent's side effects on the rest of the body. Ultrasound, traditionally used in diagnostic medicine, is finding a place in drug delivery in connection with these nanoparticles. In addition to their non-invasive nature and the fact that they can be focused on targeted tissues, acoustic waves have been credited with releasing pharmacological agents from nanocarriers, as well as rendering cell membranes more permeable. In this article, we summarize new technologies that combine the use of nanoparticles with acoustic power both in drug and gene delivery. Ultrasonic drug delivery from micelles usually employs polyether block copolymers and has been found effective in vivo for treating tumors. Ultrasound releases drug from micelles, most probably via shear stress and shock waves from the collapse of cavitation bubbles. Liquid emulsions and solid nanoparticles are used with ultrasound to deliver genes in vitro and in vivo. The small packaging allows nanoparticles to extravasate into tumor tissues. Ultrasonic drug and gene delivery from nanocarriers has tremendous potential because of the wide variety of drugs and genes that could be delivered to targeted tissues by fairly non-invasive means.

Citing Articles

Design and Characterization of a Gene-Encoding DNA Nanoparticle in a Cell-Free Transcription-Translation System.

Galvan A, Green C, Hooe S, Oktay E, Thakur M, Diaz S ACS Appl Nano Mater. 2025; 7(11):12891-12902.

PMID: 39830902 PMC: 11741557. DOI: 10.1021/acsanm.4c01456.

Drug Release via Ultrasound-Activated Nanocarriers for Cancer Treatment: A Review.

Al Refaai K, AlSawaftah N, Abuwatfa W, Husseini G Pharmaceutics. 2024; 16(11).

PMID: 39598507 PMC: 11597164. DOI: 10.3390/pharmaceutics16111383.

Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy.

Georgeous J, AlSawaftah N, Abuwatfa W, Husseini G Pharmaceutics. 2024; 16(10).

PMID: 39458661 PMC: 11510955. DOI: 10.3390/pharmaceutics16101332.

Biopolymeric nanocarriers in cancer therapy: unleashing the potency of bioactive anticancer compounds for enhancing drug delivery.

Hadkar V, Mohanty C, Selvaraj C RSC Adv. 2024; 14(35):25149-25173.

PMID: 39139249 PMC: 11317881. DOI: 10.1039/d4ra03911d.

Tween 80-Based Self-Assembled Mixed Micelles Boost Valsartan Transdermal Delivery.

Yassin A, Massadeh S, Alshwaimi A, Kittaneh R, Omer M, Ahmad D Pharmaceuticals (Basel). 2024; 17(1).

PMID: 38256853 PMC: 10819404. DOI: 10.3390/ph17010019.

References

Hosseinkhani H, Aoyama T, Ogawa O, Tabata Y . Ultrasound enhancement of in vitro transfection of plasmid DNA by a cationized gelatin. J Drug Target. 2002; 10(3):193-204. DOI: 10.1080/10611860290022624. View

Chen Y, Liang H, Zhang Q, Blomley M, Lu Q . Pluronic block copolymers: novel functions in ultrasound-mediated gene transfer and against cell damage. Ultrasound Med Biol. 2005; 32(1):131-7. DOI: 10.1016/j.ultrasmedbio.2005.10.002. View

Sivakumar M, Tachibana K, Pandit A, Yasui K, Tuziuti T, Towata A . Transdermal drug delivery using ultrasound-theory, understanding and critical analysis. Cell Mol Biol (Noisy-le-grand). 2005; 51 Suppl:OL767-84. View

Kwon G, Naito M, Yokoyama M, Okano T, Sakurai Y, Kataoka K . Physical entrapment of adriamycin in AB block copolymer micelles. Pharm Res. 1995; 12(2):192-5. DOI: 10.1023/a:1016266523505. View

Sarker D . Engineering of nanoemulsions for drug delivery. Curr Drug Deliv. 2005; 2(4):297-310. DOI: 10.2174/156720105774370267. View

Kabanov A, Alakhov V . Pluronic block copolymers in drug delivery: from micellar nanocontainers to biological response modifiers. Crit Rev Ther Drug Carrier Syst. 2002; 19(1):1-72. DOI: 10.1615/critrevtherdrugcarriersyst.v19.i1.10. View

Aoyama T, Hosseinkhani H, Yamamoto S, Ogawa O, Tabata Y . Enhanced expression of plasmid DNA-cationized gelatin complex by ultrasound in murine muscle. J Control Release. 2002; 80(1-3):345-56. DOI: 10.1016/s0168-3659(02)00029-9. View

Unger E, Porter T, Culp W, LaBell R, Matsunaga T, Zutshi R . Therapeutic applications of lipid-coated microbubbles. Adv Drug Deliv Rev. 2004; 56(9):1291-314. DOI: 10.1016/j.addr.2003.12.006. View

Apfel R, Holland C . Gauging the likelihood of cavitation from short-pulse, low-duty cycle diagnostic ultrasound. Ultrasound Med Biol. 1991; 17(2):179-85. DOI: 10.1016/0301-5629(91)90125-g. View

10.

Zhou Q, Miller D, Carlisle R, Seymour L, Oupicky D . Ultrasound-enhanced transfection activity of HPMA-stabilized DNA polyplexes with prolonged plasma circulation. J Control Release. 2005; 106(3):416-27. DOI: 10.1016/j.jconrel.2005.05.002. View

11.

Husseini G, Myrup G, Pitt W, Christensen D, Rapoport N . Factors affecting acoustically triggered release of drugs from polymeric micelles. J Control Release. 2000; 69(1):43-52. DOI: 10.1016/s0168-3659(00)00278-9. View

12.

Benns J, Kim S . Tailoring new gene delivery designs for specific targets. J Drug Target. 2000; 8(1):1-12. DOI: 10.3109/10611860009009205. View

13.

Zhou Q, Gallo J . In vivo microdialysis for PK and PD studies of anticancer drugs. AAPS J. 2005; 7(3):E659-67. PMC: 2751268. DOI: 10.1208/aapsj070366. View

14.

Goss S, Johnston R, Dunn F . Compilation of empirical ultrasonic properties of mammalian tissues. II. J Acoust Soc Am. 1980; 68(1):93-108. DOI: 10.1121/1.384509. View

15.

Chumakova O, Liopo A, Andreev V, Cicenaite I, Evers B, Chakrabarty S . Composition of PLGA and PEI/DNA nanoparticles improves ultrasound-mediated gene delivery in solid tumors in vivo. Cancer Lett. 2008; 261(2):215-25. DOI: 10.1016/j.canlet.2007.11.023. View

16.

Rapoport N, Pitina L . Intracellular distribution and intracellular dynamics of a spin-labeled analogue of doxorubicin fluorescence and EPR spectroscopy. J Pharm Sci. 1998; 87(3):321-5. DOI: 10.1021/js970271g. View

17.

Rooney J . Hemolysis near an ultrasonically pulsating gas bubble. Science. 1970; 169(3948):869-71. DOI: 10.1126/science.169.3948.869. View

18.

Rapoport N, Herron J, Pitt W, Pitina L . Micellar delivery of doxorubicin and its paramagnetic analog, ruboxyl, to HL-60 cells: effect of micelle structure and ultrasound on the intracellular drug uptake. J Control Release. 1999; 58(2):153-62. DOI: 10.1016/s0168-3659(98)00149-7. View

19.

Lawrie A, Brisken A, Francis S, Cumberland D, Crossman D, Newman C . Microbubble-enhanced ultrasound for vascular gene delivery. Gene Ther. 2001; 7(23):2023-7. DOI: 10.1038/sj.gt.3301339. View

20.

Pechar M, Ulbrich K, Subr V, Seymour L, Schacht E . Poly(ethylene glycol) multiblock copolymer as a carrier of anti-cancer drug doxorubicin. Bioconjug Chem. 2000; 11(2):131-9. DOI: 10.1021/bc990092l. View