The Yin and Yang of YY1 in the Nervous System

Overview

Journal J Neurochem

Specialties Chemistry
Neurology

Date 2008 May 20

PMID 18485096

Citations 67

Authors

Ye He

Patrizia Casaccia-Bonnefil

Affiliations

Soon will be listed here.

Abstract

The transcription factor Yin Yang 1 (YY1) is a multifunctional protein that can activate or repress gene expression depending on the cellular context. YY1 is ubiquitously expressed and highly conserved between species. However, its role varies in diverse cell types and includes proliferation, differentiation, and apoptosis. This review will focus on the function of YY1 in the nervous system including its role in neural development, neuronal function, developmental myelination, and neurological disease. The multiple functions of YY1 in distinct cell types are reviewed and the possible mechanisms underlying the cell specificity for these functions are discussed.

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