The Induction of Tumour Cell Adhesiveness and Intercellular Junctions by a Glycoprotein of Rat Ascites Hepatoma Cell Surface

Overview

Journal Br J Cancer

Specialty Oncology

Date 1976 Oct 1

PMID 184812

Citations 7

Authors

Y Ishimaru

K Kudo

H Ishihara

H Hayashi

Affiliations

Soon will be listed here.

Abstract

Rat ascites hepatoma AH109A cells (present as a free form in vivo) can aggregate and then develop well-defined tripartite junctional complexes, including intermediate junctions, desmosomes and focal tight junctions, on incubation with a glycoprotein separated from rat ascites hepatoma AH136B cells (forming cell islnds in vivo). The development of binding structures was strongly inhibited by actinomycin D. AH109A cells or rat ascites hepatoma YS cells (present as a free form in vivo) previously treated with the glycoprotein for 24 h, when inoculated i.p., proliferated as free cells in the ascitic fluid, like the untreated cells. AH109A cells actively proliferating in the skin do not form any junctional complexes. The reason for the failure of island formation by AH109A cells or YS cells in vivo is discussed.

Citing Articles

A monoclonal antibody disrupting cell-cell adhesion of rat ascites hepatoma cells.

Ohshima S, Ishimaru Y, Honda M, Ohkawara S, Ogawa M Cell Tissue Res. 1993; 273(2):363-70.

PMID: 8364973 DOI: 10.1007/BF00312839.

Desmosome development in an in vitro model.

DEMBITZER H, Herz F, Schermer A, Wolley R, Koss L J Cell Biol. 1980; 85(3):695-702.

PMID: 7190148 PMC: 2111458. DOI: 10.1083/jcb.85.3.695.

Immunological function of adhesive glycoprotein from rat ascites hepatoma cells: production of macrophage chemotactic lymphokine.

Hifumi M, Hayashi H Immunology. 1983; 49(2):245-53.

PMID: 6602088 PMC: 1454190.

Cell membrane polarity in rat ascites hepatoma cells. Distribution of a cell surface-associated adhesive factor on the cell surfaces.

Ishimaru Y, Hattori R, Chen J, Hayashi H Cell Tissue Res. 1985; 240(2):353-9.

PMID: 3995556 DOI: 10.1007/BF00222345.

An adhesive glycoprotein from rat ascites hepatoma cells potentiates natural cytotoxic activity by rat spleen cells.

Chen J, Kurano R, Hirashima M, Hayashi H Immunology. 1986; 58(1):95-100.

PMID: 3710521 PMC: 1452625.

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