The Effect on Gastric Tone of Gastric Electrical Stimulation with Trains of Short Pulses Varies with Sites and Stimulation Conditions

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2008 May 16

PMID 18481178

Citations 4

Authors

Yong Lei

Jinhong Xing

Jiande Chen

Affiliations

Soon will be listed here.

Abstract

Background: Gastric electrical stimulation (GES) can improve symptoms in patients with gastroparesis and induce weight loss in obese subjects.

Aims: To evaluate the effect on gastric tone of GES under different conditions at different sites of the stomach.

Methods: Eleven dogs were implanted with a gastric cannula and two pairs of stimulation electrodes (in the middle of the lesser curvature and of the greater curvature, 10 cm from the pylorus). Gastric tone was assessed with a barostat. GES was applied using: (1) Enterra conditions (14 Hz, 5 mA, 0.3 ms, 0.1 s on, 5 s off); (2) modified Enterra conditions (40 Hz, 5 mA, 0.3 ms, 0.1 s on, 5 s off); and (3) implantable gastric stimulation (IGS) conditions (40 Hz, 5 mA, 0.3 ms, 2 s on, 3 s off). Six sessions were performed randomly with each animal on six separate days.

Results: (1) At the lesser curvature, GES with modified Enterra conditions significantly elevated gastric volume from 96.9 +/- 8.3 ml at baseline to 133.9 +/- 11.7 ml (P = 0.015) and a similar effect was observed with IGS (91.3 +/- 7.1 ml vs. 186.3 +/- 27.1 ml, P = 0.013). GES with Enterra conditions had no such an effect. (2) At the greater curvature, GES with Enterra conditions significantly increased gastric volume from basal 94.1 +/- 4.4 ml to 122.1 +/- 11.3 ml (P = 0.032); modified Enterra conditions had the opposite effect (96.5 +/- 9.0 ml vs. 77.4 +/- 11.7 ml, P = 0.025) and no significant effect was observed with IGS conditions.

Conclusion: The effects of GES on gastric tone vary with the conditions and sites of stimulation. These findings may help to explain the distinct effects of GES therapy in patients with gastroparesis and obesity.

Citing Articles

Early experience with customized, meal-triggered gastric electrical stimulation in obese patients.

Miras M, Serrano M, Duran C, Valino C, Canton S Obes Surg. 2014; 25(1):174-9.

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Updates on gastric electrical stimulation to treat obesity: Systematic review and future perspectives.

Cha R, Marescaux J, Diana M World J Gastrointest Endosc. 2014; 6(9):419-31.

PMID: 25228944 PMC: 4163724. DOI: 10.4253/wjge.v6.i9.419.

Parameter selection and stimulating effects of an adjustable gastric electrical stimulator in dogs.

Guo X, Li Y, Yao S, Chen S, Du Y, Wang Z Obes Surg. 2013; 24(1):78-84.

PMID: 23868140 PMC: 3889984. DOI: 10.1007/s11695-013-1037-5.

Effects of dual pulse gastric electrical stimulation on gastric tone and compliance in dogs.

Lei Y, Chen J Dig Liver Dis. 2008; 41(4):277-82.

PMID: 18799372 PMC: 2678900. DOI: 10.1016/j.dld.2008.07.312.

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