Enantioselective Assembly of Substituted Dihydropyrones Via Organocatalytic Reaction in Water Media

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2008 May 15

PMID 18476713

Citations 4

Authors

Jing Wang

Fang Yu

Xiaojing Zhang

Dawei Ma

Affiliations

Soon will be listed here.

Abstract

The diarylprolinol ether/HOAc-catalyzed cascade Michael addition and cyclization of aldehydes and alpha-keto-alpha,beta-unsaturated esters proceeds smoothly in water to afford cyclic hemiacetals, which are oxidized to furnish highly functionalized 3,4,5,6-tetrasubstituted dihydropyrones with excellent enantioselectivities.

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