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Human Immunodeficiency Virus-associated Nephropathy in Pregnancy

Overview
Journal Infect Dis Obstet Gynecol
Publisher Wiley
Specialties Gynecology & Obstetrics
Infectious Diseases
Date 1996 Jan 1
PMID 18476073
Authors
N L Eriksen
J M Mastrobattista
Affiliations
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Abstract

Background: Human immunodeficiency virus (HIV)-associated nephropathy typically leads to endstage renal disease requiring dialysis within 3-4 months. This report describes the prenatal course of a patient with HIV-associated nephropathy requiring dialysis during pregnancy.

Case: A 23-year-old nulliparous, black female presented at 13 weeks gestation with a history of HIV-associated nephropathy and anemia. She had a CD4 count of 350/mm(3), a total urinary protein of 1.7 g/day, and a serum creatinine of 4.8 mg/dl. The patient was begun on zidovudine, 500 mg daily, and erythropoietin, 4,000 units weekly. At 23 weeks gestation, when she developed hypertension, a total urinary protein of 3.4 g/day, and a serum creatinine of 4.4 mg/dl, she was hospitalized. Her renal function continued to deteriorate, requiring hemodialysis. At 29-4/7 weeks, she developed preterm labor, for which she was placed on indomethacin. Four days later, at 30 weeks gestation, she delivered a viable male infant.

Conclusion: HIV-associated nephropathy during pregnancy can be successfully managed with hemodialysis.

References
1.
Carbone L, DAgati V, Cheng J, Appel G . Course and prognosis of human immunodeficiency virus-associated nephropathy. Am J Med. 1989; 87(4):389-95. DOI: 10.1016/s0002-9343(89)80819-8. View
2.
Rao T . A decade of human immunodeficiency virus-associated nephropathy (HIVAN). Transplant Proc. 1993; 25(4):2439-40. View
3.
Hou S, Orlowski J, Pahl M, Ambrose S, Hussey M, Wong D . Pregnancy in women with end-stage renal disease: treatment of anemia and premature labor. Am J Kidney Dis. 1993; 21(1):16-22. DOI: 10.1016/s0272-6386(12)80714-1. View
4.
Ortiz C, Meneses R, Jaffe D, Fernandez J, Perez G, Bourgoignie J . Outcome of patients with human immunodeficiency virus on maintenance hemodialysis. Kidney Int. 1988; 34(2):248-53. DOI: 10.1038/ki.1988.172. View
5.
Michel C, Dosquet P, Ronco P, Mougenot B, Viron B, Mignon F . Nephropathy associated with infection by human immunodeficiency virus: a report on 11 cases including 6 treated with zidovudine. Nephron. 1992; 62(4):434-40. DOI: 10.1159/000187094. View