The Effect of Steroid Treatment on Lipocortin Immunoreactivity of Rat Brain

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 1994 Jan 1

PMID 18472938

Citations 3

Authors

K G Go

J G Ter Haar

L de Ley

F Zuiderveen

L Parente

E Solito

W M Molenaar

Affiliations

Soon will be listed here.

Abstract

Lipocortin-1, lipocortin-2 and lipocortin-5 were immunohistochemically assessed in rats. Apart from animals receiving no treatment, other animals received pretreatment with methylprednisolone, or the 21-aminosteroid U-74389F. Whereas Hpocortin immunoreactivity was absent in the greater part of the brain in animals not pretreated with steroid (except in sporadic microglial cells and choroid plexus), there was obvious immunostaining of parenchymatous elements in steroid pretreated animals. In the steroid pretreated animals lipocortin immunoreactivity of the brain tissue may indicate local formation of lipocortin under the influence of steroids that had entered the tissue. The cellular elements which showed immunostaining included meningeal cells, neurones, ependyma, oligodendroglia and capillary endotheHum.

Citing Articles

Endothelial Response to Glucocorticoids in Inflammatory Diseases.

Zielinska K, Van Moortel L, Opdenakker G, De Bosscher K, Van den Steen P Front Immunol. 2016; 7:592.

PMID: 28018358 PMC: 5155119. DOI: 10.3389/fimmu.2016.00592.

Induction of annexin-1 at transcriptional and post-transcriptional level in rat brain by methylprednisolone and the 21-aminosteroid U74389F.

Voermans P, Go K, Horst G, Ruiters M, Solito E, Parente L Mediators Inflamm. 1996; 5(5):370-8.

PMID: 18475732 PMC: 2365797. DOI: 10.1155/S0962935196000531.

Down-regulation of microglial cyclo-oxygenase-2 and inducible nitric oxide synthase expression by lipocortin 1.

Minghetti L, Nicolini A, Polazzi E, Greco A, Perretti M, Parente L Br J Pharmacol. 1999; 126(6):1307-14.

PMID: 10217523 PMC: 1565901. DOI: 10.1038/sj.bjp.0702423.

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