Value of Apparent Diffusion Coefficient Calculation Before and After Gustatory Stimulation in the Diagnosis of Acute or Chronic Parotitis

Overview

Journal Eur Radiol

Specialty Radiology

Date 2008 May 7

PMID 18458907

Citations 7

Authors

T Ries

C Arndt

M Regier

J Graessner

M C Cramer

F Reitmeier

M Jaehne

G Adam

C R Habermann

Affiliations

Soon will be listed here.

Abstract

The purpose of the study was to investigate the value of diffusion-weighted (DW) echo-planar imaging (EPI) for quantifying physiological changes of the parotid gland before and after gustatory stimulation in patients suffering from acute or chronic recurrent inflammation in comparison with healthy volunteers. Using a DW-EPI sequence at 1.5 T, parotid glands of 19 consecutive patients with acute (n=14) and chronic (n=5) inflammation of parotid glands and 52 healthy volunteers were examined. Magnetic-resonance (MR) images were obtained before and after gustatory stimulation with 5 cc of lemon juice. In volunteers mean ADC values of 1.14 x 10(-3) mm(2)/s before and 1.2 x 10(-3) mm(2)/s after gustatory stimulation were observed. In acute inflammation ADC values were higher before [1.22 x 10(-3) mm(2)/s (p=0.006)] and after stimulation [1.32 x 10(-3) mm(2)/s (p<0.001)]. Before stimulation ADC differences between chronic inflammation (1.05 x 10(-3) mm(2)/s) and healthy volunteers (p=0.04) as well as between acute and chronic inflammation (p=0.005) were statistically significant. No differences were detected after stimulation between chronic inflammation (1.2 x 10(-3) mm(2)/s) and healthy volunteers (p=0.94) and between acute and chronic inflammation (p=0.15), respectively. DW-EPI seems to display the physiological changes of the parotid gland in patients suffering from acute or chronic inflammation and might be useful for discriminating healthy from affected glands.

Citing Articles

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References

Zhang L, Murata Y, Ishida R, Ohashi I, Yoshimura R, Shibuya H . Functional evaluation with intravoxel incoherent motion echo-planar MRI in irradiated salivary glands: a correlative study with salivary gland scintigraphy. J Magn Reson Imaging. 2001; 14(3):223-9. DOI: 10.1002/jmri.1177. View

Fiehler J, Fiebach J, Gass A, Hoehn M, Kucinski T, Neumann-Haefelin T . Diffusion-weighted imaging in acute stroke--a tool of uncertain value?. Cerebrovasc Dis. 2002; 14(3-4):187-96. DOI: 10.1159/000065675. View

Thoeny H, De Keyzer F, Claus F, Sunaert S, Hermans R . Gustatory stimulation changes the apparent diffusion coefficient of salivary glands: initial experience. Radiology. 2005; 235(2):629-34. DOI: 10.1148/radiol.2352040127. View

Mishra A, Gupta R, Saksena S, Prasad K, Pandey C, Rathore D . Biological correlates of diffusivity in brain abscess. Magn Reson Med. 2005; 54(4):878-85. DOI: 10.1002/mrm.20645. View

Habermann C, Gossrau P, Kooijman H, Graessner J, Cramer M, Kaul M . Monitoring of gustatory stimulation of salivary glands by diffusion-weighted MR imaging: comparison of 1.5T and 3T. AJNR Am J Neuroradiol. 2007; 28(8):1547-51. PMC: 8134380. DOI: 10.3174/ajnr.A0587. View

Patel R, Carlos R, Midia M, Mukherji S . Apparent diffusion coefficient mapping of the normal parotid gland and parotid involvement in patients with systemic connective tissue disorders. AJNR Am J Neuroradiol. 2004; 25(1):16-20. PMC: 7974152. View

Kastrup O, Wanke I, Maschke M . Neuroimaging of infections. NeuroRx. 2005; 2(2):324-32. PMC: 1064994. DOI: 10.1602/neurorx.2.2.324. View

Sumi M, Takagi Y, Uetani M, Morikawa M, Hayashi K, Kabasawa H . Diffusion-weighted echoplanar MR imaging of the salivary glands. AJR Am J Roentgenol. 2002; 178(4):959-65. DOI: 10.2214/ajr.178.4.1780959. View

Le Bihan D, Breton E, lAllemand D, Aubin M, VIGNAUD J, LAVAL-JEANTET M . Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology. 1988; 168(2):497-505. DOI: 10.1148/radiology.168.2.3393671. View

10.

Yoshino N, Yamada I, Ohbayashi N, Honda E, Ida M, Kurabayashi T . Salivary glands and lesions: evaluation of apparent diffusion coefficients with split-echo diffusion-weighted MR imaging--initial results. Radiology. 2001; 221(3):837-42. DOI: 10.1148/radiol.2213010131. View

11.

Habermann C, Cramer M, Graessner J, Gossrau P, Reitmeier F, Fiehler J . Functional imaging of parotid glands: diffusion-weighted echo-planar MRI before and after stimulation. Rofo. 2004; 176(10):1385-9. DOI: 10.1055/s-2004-813564. View

12.

Howlett D, Menezes L, Lewis K, Moody A, Violaris N, Williams M . Sonographically guided core biopsy of a parotid mass. AJR Am J Roentgenol. 2006; 188(1):223-7. DOI: 10.2214/AJR.05.1549. View

13.

Habermann C, Gossrau P, Graessner J, Arndt C, Cramer M, Reitmeier F . Diffusion-weighted echo-planar MRI: a valuable tool for differentiating primary parotid gland tumors?. Rofo. 2005; 177(7):940-5. DOI: 10.1055/s-2005-858297. View

14.

Motoori K, Yamamoto S, Ueda T, Nakano K, Muto T, Nagai Y . Inter- and intratumoral variability in magnetic resonance imaging of pleomorphic adenoma: an attempt to interpret the variable magnetic resonance findings. J Comput Assist Tomogr. 2004; 28(2):233-46. DOI: 10.1097/00004728-200403000-00014. View

15.

Matsushima N, Maeda M, Takamura M, Takeda K . Apparent diffusion coefficients of benign and malignant salivary gland tumors. Comparison to histopathological findings. J Neuroradiol. 2007; 34(3):183-9. DOI: 10.1016/j.neurad.2007.04.002. View