BAFF and the Plasticity of Peripheral B Cell Tolerance

Overview

Journal Curr Opin Immunol

Publisher Elsevier

Specialty Allergy & Immunology

Date 2008 May 6

PMID 18456486

Citations 47

Authors

Jason E Stadanlick

Michael P Cancro

Affiliations

Soon will be listed here.

Abstract

BAFF and its receptors play a crucial role in peripheral B cell selection and survival, by dictating the set point for mature primary B cell numbers and adjusting thresholds for specificity-based selection during transitional differentiation. The notion that selective stringency can be varied on the basis of homeostatic demands reveals a previously unappreciated degree of plasticity in B cell tolerance, and suggests a paradigm that unites peripheral negative and positive selection with the maintenance of mature B cell numbers. Moreover, it implies a developmentally regulated coupling of BCR and BAFF receptors at the transitional stages and beyond.

Citing Articles

The Marginal Zone B Cell Compartment and T Cell-independent Antibody Responses Are Supported by B Cell Intrinsic Expression of IRF1.

Peel J, Owiredu E, Rosenberg A, Silva-Sanchez A, Randall T, Kearney J J Immunol. 2024; 213(12):1771-1786.

PMID: 39451043 PMC: 11611650. DOI: 10.4049/jimmunol.2300575.

B cells and the coordination of immune checkpoint inhibitor response in patients with solid tumors.

Flippot R, Teixeira M, Rey-Cardenas M, Carril-Ajuria L, Rainho L, Naoun N J Immunother Cancer. 2024; 12(4).

PMID: 38631710 PMC: 11029261. DOI: 10.1136/jitc-2023-008636.

Dysregulated B cell function and disease pathogenesis in systemic sclerosis.

Beesley C, Goldman N, Taher T, Denton C, Abraham D, Mageed R Front Immunol. 2023; 13:999008.

PMID: 36726987 PMC: 9885156. DOI: 10.3389/fimmu.2022.999008.

Systemic Lupus Erythematosus and Immunodeficiency.

Chan S, Lau C Rheumatol Immunol Res. 2022; 2(3):131-138.

PMID: 36465072 PMC: 9524792. DOI: 10.2478/rir-2021-0019.

The impact of Epstein-Barr virus latent membrane protein 2A on the production of B cell activating factor of the tumor necrosis factor family (BAFF), APRIL and their receptors.

Madayag K, Incrocci R, Swanson-Mungerson M Immun Inflamm Dis. 2022; 10(11):e729.

PMID: 36301035 PMC: 9597489. DOI: 10.1002/iid3.729.

References

Miller J, Stadanlick J, Cancro M . Space, selection, and surveillance: setting boundaries with BLyS. J Immunol. 2006; 176(11):6405-10. DOI: 10.4049/jimmunol.176.11.6405. View

Nossal G, Pike B . Evidence for the clonal abortion theory of B-lymphocyte tolerance. J Exp Med. 1975; 141(4):904-17. PMC: 2189748. View

Claudio E, Brown K, Siebenlist U . NF-kappaB guides the survival and differentiation of developing lymphocytes. Cell Death Differ. 2006; 13(5):697-701. DOI: 10.1038/sj.cdd.4401894. View

Wardemann H, Yurasov S, Schaefer A, Young J, Meffre E, Nussenzweig M . Predominant autoantibody production by early human B cell precursors. Science. 2003; 301(5638):1374-7. DOI: 10.1126/science.1086907. View

Fulcher D, Basten A . Reduced life span of anergic self-reactive B cells in a double-transgenic model. J Exp Med. 1994; 179(1):125-34. PMC: 2191321. DOI: 10.1084/jem.179.1.125. View

Lentz V, Cancro M, Nashold F, Hayes C . Bcmd governs recruitment of new B cells into the stable peripheral B cell pool in the A/WySnJ mouse. J Immunol. 1996; 157(2):598-606. View

Yan M, Brady J, Chan B, Lee W, Hsu B, Harless S . Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. Curr Biol. 2001; 11(19):1547-52. DOI: 10.1016/s0960-9822(01)00481-x. View

Thien M, Phan T, Gardam S, Amesbury M, Basten A, Mackay F . Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches. Immunity. 2004; 20(6):785-98. DOI: 10.1016/j.immuni.2004.05.010. View

Cyster J, Hartley S, Goodnow C . Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature. 1994; 371(6496):389-95. DOI: 10.1038/371389a0. View

10.

Sprent J, BRUCE J . Physiology of B cells in mice with X-linked immunodeficiency (xid). III. Disappearance of xid B cells in double bone marrow chimeras. J Exp Med. 1984; 160(3):711-23. PMC: 2187403. DOI: 10.1084/jem.160.3.711. View

11.

Allman D, Ferguson S, Cancro M . Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigenhi and exhibit unique signaling characteristics. J Immunol. 1992; 149(8):2533-40. View

12.

Wang H, Clarke S . Evidence for a ligand-mediated positive selection signal in differentiation to a mature B cell. J Immunol. 2003; 171(12):6381-8. DOI: 10.4049/jimmunol.171.12.6381. View

13.

Nossal G, Pike B . Clonal anergy: persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen. Proc Natl Acad Sci U S A. 1980; 77(3):1602-6. PMC: 348545. DOI: 10.1073/pnas.77.3.1602. View

14.

Harless S, Lentz V, Sah A, Hsu B, Clise-Dwyer K, Hilbert D . Competition for BLyS-mediated signaling through Bcmd/BR3 regulates peripheral B lymphocyte numbers. Curr Biol. 2001; 11(24):1986-9. DOI: 10.1016/s0960-9822(01)00598-x. View

15.

Gu H, Tarlinton D, Muller W, Rajewsky K, Forster I . Most peripheral B cells in mice are ligand selected. J Exp Med. 1991; 173(6):1357-71. PMC: 2190826. DOI: 10.1084/jem.173.6.1357. View

16.

Mecklenbrauker I, Kalled S, Leitges M, Mackay F, Tarakhovsky A . Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling. Nature. 2004; 431(7007):456-61. DOI: 10.1038/nature02955. View

17.

Beinke S, Ley S . Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J. 2004; 382(Pt 2):393-409. PMC: 1133795. DOI: 10.1042/BJ20040544. View

18.

Yurasov S, Wardemann H, Hammersen J, Tsuiji M, Meffre E, Pascual V . Defective B cell tolerance checkpoints in systemic lupus erythematosus. J Exp Med. 2005; 201(5):703-11. PMC: 2212839. DOI: 10.1084/jem.20042251. View

19.

Schneider P, Mackay F, Steiner V, Hofmann K, Bodmer J, Holler N . BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med. 1999; 189(11):1747-56. PMC: 2193079. DOI: 10.1084/jem.189.11.1747. View

20.

Freitas A, Rosado M, Viale A, Grandien A . The role of cellular competition in B cell survival and selection of B cell repertoires. Eur J Immunol. 1995; 25(6):1729-38. DOI: 10.1002/eji.1830250636. View