Effect of O6-methylguanine on the Stability of G-quadruplex DNA

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2008 May 2

PMID 18447358

Citations 20

Authors

Chongkham S Mekmaysy

Luigi Petraccone

Nichola C Garbett

Patricia A Ragazzon

Robert Gray

John O Trent

Jonathan B Chaires

Affiliations

Soon will be listed here.

Abstract

The effects of substitution of O6-methylguanine on the structure and stability of a human telomere quadruplex was studied by circular dichroism, thermal denaturation, analytical ultracentrifugation, and molecular dynamics simulations. The results show that, while quadruplex structures can form containing the modified base, they are much less stable than the normal unmodified structure. The extent of destabilization is critically dependent on the exact position of the modified base within the quadruplex structure.

Citing Articles

The Epigenomic Features and Potential Functions of PEG- and PDS-Favorable DNA G-Quadruplexes in Rice.

Huang R, Feng Y, Gao Z, Ahmed A, Zhang W Int J Mol Sci. 2024; 25(1).

PMID: 38203805 PMC: 10779103. DOI: 10.3390/ijms25010634.

Fast detection, a precise and sensitive diagnostic agent for breast cancer.

Wu Q, Yuan C, Liu N, Shu J, Wang J, Qian J J Exp Clin Cancer Res. 2022; 41(1):201.

PMID: 35698159 PMC: 9190138. DOI: 10.1186/s13046-022-02393-3.

Spectroscopic and In Silico Studies on the Interaction of Substituted Pyrazolo[1,2-a]benzo[1,2,3,4]tetrazine-3-one Derivatives with c-Myc G4-DNA.

Mulliri S, Laaksonen A, Spanu P, Farris R, Farci M, Mingoia F Int J Mol Sci. 2021; 22(11).

PMID: 34199659 PMC: 8199725. DOI: 10.3390/ijms22116028.

Position-Dependent Effect of Guanine Base Damage and Mutations on Telomeric G-Quadruplex and Telomerase Extension.

Lee H, Sanford S, Paul T, Choe J, Bose A, Opresko P Biochemistry. 2020; 59(28):2627-2639.

PMID: 32578995 PMC: 8674823. DOI: 10.1021/acs.biochem.0c00434.

Epigenetic Modulation of Chromatin States and Gene Expression by G-Quadruplex Structures.

Reina C, Cavalieri V Int J Mol Sci. 2020; 21(11).

PMID: 32545267 PMC: 7312119. DOI: 10.3390/ijms21114172.