NHERF1: Molecular Brake on the PI3K Pathway in Breast Cancer

Overview

Journal Breast Cancer Res

Specialty Oncology

Date 2008 Apr 24

PMID 18430260

Citations 14

Authors

Maria-Magdalena Georgescu

Affiliations

Soon will be listed here.

Abstract

The adaptor protein NHERF1/EBP50 (Na/H exchanger regulatory factor 1/ezrin-radixin-moesin-binding phosphoprotein 50) emerged recently as an important player in breast cancer progression. Consisting of two tandem PDZ domains linked to a carboxyl-terminal ezrin-binding region, NHERF1 assembles macromolecular complexes at the apical membrane of epithelial cells in many epithelial tissues, including the mammary gland. Involved initially in trafficking and regulation of transmembrane ion transporters and G protein-coupled receptors, NHERF1 also couples molecules involved in cell growth, such as the platelet-derived growth factor receptor (PDGFR) and PTEN (phosphatase and tensin homolog deleted on chromosome 10). In the previous issue of Breast Cancer Research, Pan and colleagues show an inhibitory action of NHERF1 on the phosphoinositide-3 kinase (PI3K)/Akt pathway in breast cancer cells via interaction of NHERF1 with PTEN, the physiological antagonist of the PI3K. Additionally, they show that NHERF1 expression confers susceptibility to PDGFR pharmacological inhibition depending on the presence of PTEN tumor suppressor.

Citing Articles

NHERF1 Is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland.

Jeong J, Kim W, Hens J, Dann P, Schedin P, Friedman P Endocrinology. 2019; 160(8):1797-1810.

PMID: 31087002 PMC: 6619491. DOI: 10.1210/en.2019-00230.

Inhibition of ezrin causes PKCα-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells.

Jeong J, Choi J, Kim W, Dann P, Takyar F, Gefter J J Biol Chem. 2018; 294(3):887-901.

PMID: 30463939 PMC: 6341383. DOI: 10.1074/jbc.RA118.004143.

The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2.

Jeong J, VanHouten J, Kim W, Dann P, Sullivan C, Choi J J Biol Chem. 2017; 292(16):6555-6568.

PMID: 28235801 PMC: 5399107. DOI: 10.1074/jbc.M116.770883.

Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevance.

Vaquero J, Nguyen Ho-Bouldoires T, Claperon A, Fouassier L Oncogene. 2017; 36(22):3067-3079.

PMID: 28068322 DOI: 10.1038/onc.2016.462.

SLC9A3R1 stimulates autophagy via BECN1 stabilization in breast cancer cells.

Liu H, Ma Y, He H, Wang J, Jiang J, Shao R Autophagy. 2015; 11(12):2323-34.

PMID: 26218645 PMC: 4835148. DOI: 10.1080/15548627.2015.1074372.

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