Levels of 1-hydroxypyrene, Symptoms and Immunologic Markers in Vulcanization Workers in the Southern Sweden Rubber Industries

Overview

Journal Int Arch Occup Environ Health

Specialty Environmental Health

Date 2008 Apr 22

PMID 18425528

Citations 3

Authors

Lena S Jonsson

Karin Broberg

Anna Axmon

Ulf Bergendorf

Margareta Littorin

Bo A G Jonsson

Affiliations

Soon will be listed here.

Abstract

Objectives: The aim of this study was to determine urinary 1-hydroxypyrene (1-HP) levels in contemporary Swedish vulcanization workers and in controls. These levels were used as an index substance for vulcanization fumes, as well as a biomarker for polycyclic aromatic hydrocarbons (PAHs). The risk of symptoms and changed levels of immunologic markers were investigated in relation to the 1-HP levels.

Methods: Included in the study were 163 exposed workers and 106 controls. Medical and occupational histories were obtained by structured interviews. Symptoms were recorded and immunologic markers analysed in blood by routine analysis methods. Levels of 1-HP were determined by liquid chromatography and fluorescence detection.

Results: The highest levels of 1-HP were found among exposed workers using injection and compression vulcanization and lower levels were found among exposed workers vulcanizing with salt bath, hot air, microwaves or fluid-bed. Compared to controls, exposed workers had increased risks of eye symptoms, nosebleeds, burning and dry throat, hoarseness, severe dry cough, nausea and headache. Furthermore, exposed workers had elevated levels of neutrophils and total IgG (immunoglobulin subclass G). However, only for severe dry cough an evident exposure-response relationship with urinary 1-HP levels was found.

Conclusions: This work clearly shows increased levels of urinary 1-HP in Swedish vulcanization workers. Furthermore, it demonstrates an increased risk of several symptoms and elevated levels of some immunologic markers in these workers. However, no obvious exposure-response relationships were found.

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References

Dor F, Dab W, Empereur-Bissonnet P, Zmirou D . Validity of biomarkers in environmental health studies: the case of PAHs and benzene. Crit Rev Toxicol. 1999; 29(2):129-68. DOI: 10.1080/10408449991349195. View

Mazzachi B, Peake M, Ehrhardt V . Reference range and method comparison studies for enzymatic and Jaffé creatinine assays in plasma and serum and early morning urine. Clin Lab. 2000; 46(1-2):53-5. View

Fine L, Peters J . Respiratory morbidity in rubber workers: I. Prevalence of respiratory symptoms and disease in curing workers. Arch Environ Health. 1976; 31(1):5-9. View

Zuskin E, Mustajbegovic J, Schachter E, Budak A . Longitudinal study of respiratory findings in rubber workers. Am J Ind Med. 1996; 30(2):171-9. DOI: 10.1002/(SICI)1097-0274(199608)30:2<171::AID-AJIM8>3.0.CO;2-3. View

Burstyn I, Boffetta P, Heederik D, Partanen T, Kromhout H, Svane O . Mortality from obstructive lung diseases and exposure to polycyclic aromatic hydrocarbons among asphalt workers. Am J Epidemiol. 2003; 158(5):468-78. DOI: 10.1093/aje/kwg180. View

Sparks P, Smith T, Fine L, Treitman R, Spiegelman D . Respiratory morbidity among processing and mill workers. A cross-sectional survey in three tire-manufacturing plants. J Occup Med. 1982; 24(9):690-5. View

Jonsson L, Broberg K, Bergendorf U, Axmon A, Littorin M, Jonsson B . Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries. Int Arch Occup Environ Health. 2007; 80(7):589-98. DOI: 10.1007/s00420-007-0171-6. View

Jonsson L, Jonsson B, Axmon A, Littorin M, Broberg K . Influence of glutathione-related genes on symptoms and immunologic markers among vulcanization workers in the southern Sweden rubber industries. Int Arch Occup Environ Health. 2007; 81(7):913-9. DOI: 10.1007/s00420-007-0285-x. View

Randem B, Ulvestad B, Burstyn I, Kongerud J . Respiratory symptoms and airflow limitation in asphalt workers. Occup Environ Med. 2004; 61(4):367-9. PMC: 1740758. DOI: 10.1136/oem.2002.006114. View

10.

Levin J . First international workshop on hydroxypyrene as a biomarker for PAH exposure in man--summary and conclusions. Sci Total Environ. 1995; 163(1-3):164-8. View

11.

Jonsson L, Broberg K, Axmon A, Jonsson B, Littorin M . Symptoms and immunologic markers among vulcanization workers in rubber industries in southern Sweden. Scand J Work Environ Health. 2007; 33(4):272-9. DOI: 10.5271/sjweh.1143. View

12.

Jongeneelen F . Benchmark guideline for urinary 1-hydroxypyrene as biomarker of occupational exposure to polycyclic aromatic hydrocarbons. Ann Occup Hyg. 2001; 45(1):3-13. View

13.

Mastrangelo G, Clonfero E, Pavanello S, Fedeli U, Fadda E, Turato A . Exposure to diesel exhaust enhances total IgE in non-atopic dockers. Int Arch Occup Environ Health. 2003; 76(1):63-8. DOI: 10.1007/s00420-002-0373-x. View

14.

Weeks J, Peters J, Monson R . Screening for occupational health hazards in the rubber industry. Part II: health hazards in the curing department. Am J Ind Med. 1981; 2(2):143-51. DOI: 10.1002/ajim.4700020208. View

15.

Nielsen J, Welinder H, Schutz A, Skerfving S . Specific serum antibodies against phthalic anhydride in occupationally exposed subjects. J Allergy Clin Immunol. 1988; 82(1):126-33. DOI: 10.1016/0091-6749(88)90062-0. View

16.

Singh R, Tucek M, Maxa K, Tenglerova J, Weyand E . A rapid and simple method for the analysis of 1-hydroxypyrene glucuronide: a potential biomarker for polycyclic aromatic hydrocarbon exposure. Carcinogenesis. 1995; 16(12):2909-15. DOI: 10.1093/carcin/16.12.2909. View

17.

Peters S, Talaska G, Jonsson B, Kromhout H, Vermeulen R . Polycyclic aromatic hydrocarbon exposure, urinary mutagenicity, and DNA adducts in rubber manufacturing workers. Cancer Epidemiol Biomarkers Prev. 2008; 17(6):1452-9. DOI: 10.1158/1055-9965.EPI-07-2777. View

18.

Talaska G, Maier A, Henn S, Booth-Jones A, Tsuneoka Y, Vermeulen R . Carcinogen biomonitoring in human exposures and laboratory research: validation and application to human occupational exposures. Toxicol Lett. 2002; 134(1-3):39-49. DOI: 10.1016/s0378-4274(02)00161-3. View

19.

Littorin M, Rylander L, Skarping G, Dalene M, Welinder H, Stromberg U . Exposure biomarkers and risk from gluing and heating of polyurethane: a cross sectional study of respiratory symptoms. Occup Environ Med. 2000; 57(6):396-405. PMC: 1739970. DOI: 10.1136/oem.57.6.396. View

20.

Buchet J, Gennart J, Delavignette J, Cupers L, Lauwerys R . Evaluation of exposure to polycyclic aromatic hydrocarbons in a coke production and a graphite electrode manufacturing plant: assessment of urinary excretion of 1-hydroxypyrene as a biological indicator of exposure. Br J Ind Med. 1992; 49(11):761-8. PMC: 1039323. DOI: 10.1136/oem.49.11.761. View