Multivariate Analysis of the Pathologic Features of Esophageal Squamous Cell Cancer: Tumor Budding is a Significant Independent Prognostic Factor

Overview

Journal Ann Surg Oncol

Publisher Springer

Specialty Oncology

Date 2008 Apr 15

PMID 18408975

Citations 48

Authors

Masahiko Koike

Yasuhiro Kodera

Yuichi Itoh

Goro Nakayama

Michitaka Fujiwara

Nobuyuki Hamajima

Akimasa Nakao

Affiliations

Soon will be listed here.

Abstract

Background: Tumor budding has been suggested to be a prognostic factor in various cancers but has never been studied in esophageal cancer.

Methods: In this study, the microscopic finding of tumor budding in esophageal squamous cell carcinoma was correlated with outcome after esophagectomy. One hundred and thirty-six patients undergoing a curative esophagectomy were assigned to either a frequent (n = 82) or rare (n = 54) group according to the microscopically observed frequency of tumor budding in the tumor.

Results: The 5-year survival rates after esophagectomy were 35.4% for the frequent group and 81.3% for the rare group. Multivariate analysis using the Cox proportional hazards model by a stepwise method identified this morphological variable as a significant independent prognostic factor.

Conclusions: Tumor budding in esophageal squamous cell carcinoma reflects the biological activity of the tumor and may be a useful prognostic indicator.

Citing Articles

Histopathological study of the localization/distribution of Fusobacterium nucleatum in esophageal cancer.

Sasaki-Higashimoto I, Fujishima F, Ishida H, Taniyama Y, Ozawa Y, Nakamura T Pathol Int. 2025; 75(2):82-91.

PMID: 39760468 PMC: 11848974. DOI: 10.1111/pin.13505.

Correlation between tumor budding and the long-term follow-up outcomes after endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma.

Liu C, Ye L, Peng T, Chen L, Zhang Y, Zhou Y Surg Endosc. 2024; 38(10):5575-5583.

PMID: 39090202 DOI: 10.1007/s00464-024-11124-y.

Significance of tumour budding and invasive characteristics in grading of oral squamous cell carcinoma.

Selvaraj F, Joseph A, Pillai V, Ramani P, Pazhani J, Mony V J Oral Maxillofac Pathol. 2024; 27(4):642-648.

PMID: 38304506 PMC: 10829472. DOI: 10.4103/jomfp.jomfp_410_23.

Prognostic Impact of Tumor Budding on Moroccan Gastric Cancer Patients.

El Yaagoubi S, Zaryouhi M, Benmaamar S, Agy F, Tahiri El Ousrouti L, Hammas N Clin Pathol. 2023; 16:2632010X231184329.

PMID: 37426068 PMC: 10326459. DOI: 10.1177/2632010X231184329.

Invasive features of superficial oesophageal squamous cell carcinoma-analysis of risk factors for lymph node metastasis.

Kato Y, Ito T, Yamamoto K, Furukawa A, Shintaku H, Yamamoto K Virchows Arch. 2023; 483(5):645-653.

PMID: 37341813 DOI: 10.1007/s00428-023-03582-x.