T-helper 17 Cells in Psoriatic Plaques and Additional Genetic Links Between IL-23 and Psoriasis

Overview

Journal J Invest Dermatol

Publisher Elsevier

Specialty Dermatology

Date 2008 Apr 15

PMID 18408745

Citations 56

Authors

Andrew Blauvelt

Affiliations

Soon will be listed here.

Abstract

T-helper 17 (Th17) cells are a newly appreciated T-cell subset, distinct from both Th1 and Th2 cells, that have been implicated in the pathogenesis of psoriasis and other autoimmune inflammatory diseases (Figure 1) (Fitch et al., 2007; Kastelein et al., 2007). IL-23 stimulates survival and proliferation of Th17 cells and thus serves as a key master cytokine regulator for these diseases.

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