Structure-specific Statistical Mapping of White Matter Tracts

Overview

Journal Neuroimage

Specialty Radiology

Date 2008 Apr 15

PMID 18407524

Citations 95

Authors

Paul A Yushkevich

Hui Zhang

Tony J Simon

James C Gee

Affiliations

Soon will be listed here.

Abstract

We present a new model-based framework for the statistical analysis of diffusion imaging data associated with specific white matter tracts. The framework takes advantage of the fact that several of the major white matter tracts are thin sheet-like structures that can be effectively modeled by medial representations. The approach involves segmenting major tracts and fitting them with deformable geometric medial models. The medial representation makes it possible to average and combine tensor-based features along directions locally perpendicular to the tracts, thus reducing data dimensionality and accounting for errors in normalization. The framework enables the analysis of individual white matter structures, and provides a range of possibilities for computing statistics and visualizing differences between cohorts. The framework is demonstrated in a study of white matter differences in pediatric chromosome 22q11.2 deletion syndrome.

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