Insulin Signal Transduction Pathways

Overview

Journal Trends Endocrinol Metab

Specialty Endocrinology

Date 1994 Nov 1

PMID 18407232

Citations 4

Authors

M J Quon

A J Butte

S I Taylor

Affiliations

Soon will be listed here.

Abstract

Insulin initiates its pleiotropic effects by activating the insulin receptor tyrosine kinase to phosphorylate several intracellular proteins. Recent studies have demonstrated that phosphotyrosine residues bind specifically to proteins that contain src homology 2 (SH2) domains, and that this interaction mediates the regulation of multiple intracellular signaling pathways. This article reviews recent progress in elucidating the detailed pathways that lead from the insulin receptor to the ultimate biologic actions of insulin.

Citing Articles

Targeted Inhibition of Protein Tyrosine Phosphatase 1B by Viscosol Ameliorates Type 2 Diabetes Pathophysiology and Histology in Diabetic Mouse Model.

Sohail A, Fayyaz H, Muneer H, Raza I, Ikram M, Uddin Z Biomed Res Int. 2023; 2022:2323078.

PMID: 36875821 PMC: 9977540. DOI: 10.1155/2022/2323078.

Sequestosome 1/p62, a scaffolding protein, is a newly identified partner of IRS-1 protein.

Geetha T, Zheng C, Vishwaprakash N, Broderick T, Babu J J Biol Chem. 2012; 287(35):29672-8.

PMID: 22761437 PMC: 3436154. DOI: 10.1074/jbc.M111.322404.

Rosiglitazone ameliorates abnormal expression and activity of protein tyrosine phosphatase 1B in the skeletal muscle of fat-fed, streptozotocin-treated diabetic rats.

Wu Y, Ouyang J, Wu K, Wang S, Wen C, Xia Z Br J Pharmacol. 2005; 146(2):234-43.

PMID: 15997237 PMC: 1576260. DOI: 10.1038/sj.bjp.0706306.

Insulin signaling inhibits the 5-HT2C receptor in choroid plexus via MAP kinase.

Hurley J, Zhang S, Bye L, Marshall M, DePaoli-Roach A, Guan K BMC Neurosci. 2003; 4:10.

PMID: 12795815 PMC: 165579. DOI: 10.1186/1471-2202-4-10.